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Active Ingredient: Losartan
Brand Name: Hyzaar

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What is Hyzaar

Hyzaar is a combination of an angiotensin II receptor antagonist and a thiazide diuretic (water pill) used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease. Hyzaar is available in generic form.

Hyzaar Drug Recommendation

Hypertension: Diuretics, β-blockers, calcium antagonists (dihydropyridines), angiotensin changing enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) successfully decrease blood stress and scale back the 10-year threat of cardiovascular mortality and morbidity. Comorbidity and particular affected person traits decide which teams and which brokers needs to be thought of first. Medication with 24-hour efficacy are most well-liked. If one drug is insufficiently efficient on the really useful dose, including a drug from one other group is simpler than rising the dose; it additionally limits dose-dependent uncomfortable side effects. A hard and fast mixture within the appropriate dose ratio is most well-liked for causes of compliance.

Indications: Hypertension, which has not responded adequately to an ARB or a thiazide diuretic as monotherapy.

What Should You Discuss To Your Doctor Before Using This Medicine

  1. Being pregnant
    • Hydrochlorothiazide crosses the placenta.
    • Teratogenesis: Hyzaar:
      • Use of ARBs throughout the second and third trimesters is dangerous
      •  manifesting as neonatal lung hypoplasia
      • intrauterine progress retardation
      • persistent ductus arteriosus and cranium hypoplasia
    • Pharmacological impact: Use of ARBs throughout the 2nd and third trimesters might lead to foetal and/or neonatal toxicity equivalent to:
      • hypotension
      • impaired renal operate
      • renal failure
      • oligohydramnion
      • hyperkalaemia. Traditionally, use of thiazides and associated compounds within the third  trimester has been related to issues within the neonate:
        • thrombocytopenia
        • hypoglycaemia
        • disturbances in electrolyte stability
    • Recommendation: Use throughout the first trimester shouldn’t be really useful; use throughout the second and third trimesters is contraindicated.
    • Different: If you want youngsters and if you’re pregnant, it’s best to begin another remedy; it’s advisable to tell the affected person of this firstly of the therapy. If publicity has occurred from the two trimester onwards, carry out an ultrasound scan of the kidneys and cranium of the foetus. Carefully monitor newborns for:
      • hypotension
      • oliguria
      • hyperkalemia

  2. Lactation
    • Transition in breast milk: Hyzaar: sure in animals, unknown in people. Hydrochlorothiazide: sure.
    • Pharmacological impact: Elevated free bilirubin (hydrochlorothiazide).
    • Others: Thiazide diuretics might inhibit lactation attributable to fluid withdrawal.
    • Recommendation: Don’t use this medicinal product or breast-feed, particularly in untimely or neonate infants. If Hyzaar/hydrochlorothiazide needs to be used, the dose needs to be stored as little as doable.

  3. Contraindications
    • extreme renal impairment (creatinine clearance < 30 ml/min), anuria;
    • extreme hepatic impairment, cholestasis, biliary problems;
    • therapy-resistant hypokalaemia or hypercalcemia;
    • refractory hyponatraemia;
    • symptomatic hyperuricemia or gout;
    • hypersensitivity to sulphonamides.

Hyzaar Drug Interactions

Mixed use of an ARB with an ACE inhibitor or with aliskiren will increase the danger of hypotension, syncope, hyperkalaemia and deterioration of renal operate (together with acute renal failure); double blockade ought to solely be used beneath the supervision of a specialized physician in individually outlined sufferers (with out diabetic nephropathy) in whom renal operate, blood stress and electrolyte ranges are often monitored. In diabetic sufferers or with decreased renal operate (GFR < 60 ml/min/1.73 m²) using Hyzaar together with aliskiren is contra-indicated. In different sufferers the mix shouldn’t be really useful; if the mix is for use, periodic evaluation of renal operate, blood stress and serum electrolytes is really useful.

  • Different antihypertensive medicines and medicines that may trigger hypotension:
    • tricyclic antidepressants
    • antipsychotics
    • baclofen
    • narcotic analgesics
  • NSAIDs (incl. COX2 inhibitors and acetylsalicylic acid > 3 g/day) might scale back the diuretic, natriuretic and antihypertensive impact and worsen renal operate with a rise in serum potassium focus.
  • Potassium-sparing diuretics, aldosterone antagonists, heparin, potassium dietary supplements and different plasma potassium rising medicinal merchandise might potentiate the impact on serum potassium ranges and result in hyperkalaemia, notably in renal dysfunction.
  • Renal lithium clearance decreases attributable to elevated reabsorption into the tubule: discount of the lithium dose could also be obligatory.
  • The impact of insulin and oral blood glucose reducing brokers could also be antagonized. Metformin needs to be used with warning attributable to threat of lactate acidosis.
  • Fluconazole and rifampicin might scale back the focus of the lively metabolite of Hyzaar.
  • Colestyramine might lower the resorption of hydrochlorothiazide and needs to be taken two hours after or 4 hours earlier than the mix.
  • Mixture with carbamazepine will increase the danger of hyponatraemia.
  • There’s an elevated threat of haematological reactions when mixed with medicinal merchandise that adversely have an effect on the blood depend
    • allopurinol
    • cytostatics
    • immunosuppressants together with corticosteroids
  • Haemolytic anaemia has been reported together with hydrochlorothiazide and methyldopa.
  • Sufferers who’re administered iodinated distinction media needs to be hydrated beforehand.

Hyzaar Dosage

Prior particular person dosing of each elements is really useful.

  • Hypertension
    • Adults (incl. aged)
      • Beginning and upkeep dose: ’50/12.5′ mg 1×/day, if obligatory improve after 3-4 weeks to a most of ‘100/25’ mg 1×/day. Sufferers who don’t obtain adequate blood stress discount with Hyzaar 100 mg/day could also be switched straight to ‘100/12.5’ mg 1×/day.
      • Diminished renal operate: In case of gentle to reasonable renal impairment, no dose adjustment is critical (creatinine clearance ≥30 ml/min). In case of a creatinine clearance <30 ml/min the use is contra-indicated. Use by haemodialysis sufferers shouldn’t be really useful.

Hyzaar Precautions

Particularly in instances of quantity and/or sodium depletion and in coronary heart failure, there’s a larger probability of a hypotensive response. Due to this fact, in case of extreme coronary heart failure, therapy ought to ideally be initiated clinically. Appropriate a quantity and/or sodium depletion earlier than beginning remedy.

Hypotension that happens throughout anaesthesia/surgical procedure attributable to blocked angiotensin II exercise might be corrected by quantity improve. It isn’t really useful to modify instantly from monotherapy with a thiazide diuretic to this mix with Hyzaar; because of the threat of hypotension, discontinue the diuretic for 2-3 days earlier than beginning this mix.

Warning in aortic or mitral valve stenosis or obstructive hypertrophic cardiomyopathy due to the potential threat of decreased coronary and cerebral blood circulate because of the decreased blood stress.

In case of acute eye ache or lack of visible acuity (inside just a few hours to weeks after beginning therapy), discontinue therapy instantly. Choroidal effusion with visible disturbances, acute myopia and closed-chamber glaucoma have been reported with using hydrochlorothiazide. If the attention stress is elevated, attempt to scale back it because of the threat of acute closed-chamber glaucoma. A historical past of sulphonamide or penicillin allergy could also be one of many threat elements for creating acute closed-chamber glaucoma.

Hyzaar Side Effects

  • Headache, dizziness, asthenia, fatigue, chest ache
  • Insomnia
  • Cough, an infection of the higher respiratory tract, sinusitis
  • Muscle ache, muscle cramps
  • Nausea, dyspepsia, stomach ache, diarrhoea
  • Renal insufficiency, renal failure
  • Hypoglycaemia, hyperkalaemia, slight reducing of haematocrit and haemoglobin
  • Palpitations, angina pectoris, arrhythmia, myocardial infarction, stroke
  • Dyspnoea, pulmonary oedema, pneumonitis, bronchitis, sore throat, nosebleed
  • Urinary tract an infection, nocturnal/frequent micturition
  • Hyperglycaemia
  • Arthralgia, arthritis, muscle weak point, stiffness
  • Dry mouth, toothache, salivary gland irritation, anorexia, gastritis
  • Visible disturbances, burning eyes, conjunctivitis
  • Tinnitus
  • Vertigo
  • Fever
  • Dry pores and skin, itching, alopecia, perspiration, urticaria intense flushing
  • Necrotising angiitis, vasculitis
  • Nervousness, paraesthesia, peripheral neuropathy, syncope, tremor, migraine
  • Nervousness, panic assaults, melancholy, confusion, irregular dreaming
  • Decreased libido, erectile dysfunction
  • Hyperuricemia, gout
  • Hyponatraemia, hypokalaemia, slight improve in serum urea and serum creatinine
  • Anaemia, ecchymosis, purpura, haemolysis, thrombocytopenia, agranulocytosis


Information concerning psychotic disorders, included within the review of Hyzaar, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.


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Frequently asked questions

  • What is Hyzaar?

    The medication is used to treat hypertension, left ventricular hypertrophy (increase in muscle) and diabetic nephropathy. 

  • What to do if you miss a dose?

    If you miss a dose of Hyzaar, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  • What if u take too much Hyzaar?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  • How to store Hyzaar?

    Save Hyzaar in a dry place away from sunlight at room temperature.  

  • What Should I Avoid While Taking Hyzaar?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Hyzaar. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  • What are the side effects of Hyzaar?

    Possible side effects include diarrhea muscle cramps, dizziness, insomnia, nasal congestion, persistent cough, increased serum potassium, loss of appetite, dry mouth and angioedema. 

  • What are the Contraindication?

    Hypersensitivity, pregnancy breastfeeding, infancy, arterial hypotension, hyperpotassemia. 

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Last Updated on November 14, 2021 by Toni El Clikos

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