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What is Clomipramine

Clomipramine is an irregular antipsychotic medicine. Blocks dopamine receptors of CNS as well as conflicts dopamine button in basic gangliya as well as in limbic a component of neoncephalon. It is taken at hypersensitivity, disorders of hemopoietic system (along with in anamnesis), alcoholic as well as harmful psychosis, myasthenia, comas.

Anafranil Drug Uses

Anafranil is used to deal with obsessive compulsive dysfunction (OCD). OCD is a nervous situation whereby an individual has recurring ideas or concepts or does repetitive issues as a result of they’re anxious. Anafranil is a tricyclic antidepressant (TCA). It is assumed to work within the mind by rising the exercise of the chemical serotonin.

What Should You Discuss To Your Doctor Before Using This Medicine

Suicide: Since depression is a commonly associated feature of OCD, the risk of suicide must be considered. Prescriptions for Anafranil should be written for the smallest quantity of capsules consistent with good patient management, in order to reduce the risk of overdose.

Cardiovascular Effects: Modest orthostatic decreases in blood pressure and modest tachycardia were each seen in approximately 20% of patients taking Anafranil in clinical trials; but patients were frequently asymptomatic. Among approximately 1400 patients treated with CMI in the premarketing experience who had ECGs, 1.5% developed abnormalities during treatment, compared with 3.1% of patients receiving active control drugs and 0.7% of patients receiving placebo. The most common ECG changes were PVCs, ST-T wave changes, and intraventricular conduction abnormalities. These changes were rarely associated with significant clinical symptoms. Nevertheless, caution is necessary in treating patients with known cardiovascular disease, and gradual dose titration is recommended.

Psychosis, Confusion, And Other Neuropsychiatric Phenomena: Patients treated with Anafranil have been reported to show a variety of neuropsychiatric signs and symptoms including delusions, hallucinations, psychotic episodes, confusion, and paranoia. Because of the uncontrolled nature of many of the studies, it is impossible to provide a precise estimate of the extent of risk imposed by treatment with Anafranil. As with tricyclic antidepressants to which it is closely related, Anafranil may precipitate an acute psychotic episode in patients with unrecognized schizophrenia.

Mania/Hypomania: During premarketing testing of Anafranil in patients with affective disorder, hypomania or mania was precipitated in several patients. Activation of mania or hypomania has also been reported in a small proportion of patients with affective disorder treated with marketed tricyclic antidepressants, which are closely related to Anafranil.

Hepatic Changes: During premarketing testing, Anafranil was occasionally associated with elevations in SGOT and SGPT (pooled incidence of approximately 1% and 3%, respectively) of potential clinical importance (i.e., values greater than 3 times the upper limit of normal). In the vast majority of instances, these enzyme increases were not associated with other clinical findings suggestive of hepatic injury; moreover, none were jaundiced. Rare reports of more severe liver injury, some fatal, have been recorded in foreign postmarketing experience. Caution is indicated in treating patients with known liver disease, and periodic monitoring of hepatic enzyme levels is recommended in such patients.

Clomipramine Drug Interactions

Although sure medicines shouldn’t be used collectively in any respect, in different circumstances two totally different medicines could also be used collectively even when an interplay would possibly happen. In these circumstances, your physician might need to change the dose, or different precautions could also be needed. When you’re taking this medication, it’s particularly essential that your healthcare skilled know if you’re taking any of the medicines listed beneath. The following interactions have been chosen on the idea of their potential significance and aren’t essentially all-inclusive.

Using this medication with any of the next medicines is just not advisable. Your physician might determine to not deal with you with this remedy or change a number of the different medicines you’re taking.

  • Bepridil
  • Bromopride
  • Cisapride
  • Dronedarone
  • Furazolidone
  • Grepafloxacin
  • Iproniazid
  • Isocarboxazid
  • Linezolid
  • Mesoridazine
  • Methylene Blue
  • Metoclopramide
  • Moclobemide
  • Pargyline
  • Phenelzine

Other Interactions

Other Interactions

Certain medicines shouldn’t be used at or across the time of consuming meals or consuming sure kinds of meals since interactions might happen. Using alcohol or tobacco with sure medicines can also trigger interactions to happen. The following interactions have been chosen on the idea of their potential significance and aren’t essentially all-inclusive.

Using this medication with any of the next is normally not advisable, however could also be unavoidable in some circumstances. If used collectively, your physician might change the dose or how usually you utilize this medication, or provide you with particular directions about using meals, alcohol, or tobacco.

  • Tobacco
  • Grapefruit Juice

Other Medical Problems Anafranil

Other Medical Problems

The presence of different medical issues might have an effect on using this medication. Make positive you inform your physician you probably have some other medical issues, particularly:

  • Adrenal gland tumor 
  • Alcohol abuse
  • Brain harm
  • Heart illness 
  • Hyperthyroidism
  • Hypovolemia (low blood quantity)
  • Behavior or temper modifications
  • Bipolar dysfunction 
  • Depression
  • Glaucoma (angle-closure sort)
  • Kidney illness
  • Liver illness
  • Mania or hypomania
  • Psychosis (psychological sickness) 
  • Schizophrenia (psychological sickness)
  • Seizures
  • Urinary retention (bother urinating)
  • Heart assault

Proper Usage of Clomipramine

  • Take this medication solely as directed by your physician. Do not take extra of it, don’t take it extra usually, and don’t take it for an extended time than your physician ordered.
  • This medication ought to include a Medication Guide. Read and comply with these directions rigorously. Ask your physician or pharmacist you probably have any questions.
  • It is greatest to take this medication with meals. Take this medication at bedtime to minimize drowsiness through the day.

Clomipramine Dosage

The dose of this medication shall be totally different for various sufferers. Follow your physician’s orders or the instructions on the label. The following data consists of solely the common doses of this medication. If your dose is totally different, don’t change it except your physician tells you to take action.

The quantity of drugs that you simply take relies on the power of the drugs. Also, the variety of doses you’re taking every day, the time allowed between doses, and the size of time you’re taking the drugs depend upon the medical downside for which you’re utilizing the drugs.

  • For oral dosage kind (capsules):
    • For obsessive-compulsive dysfunction:
      • Adults: At first, 25 milligrams (mg) as soon as a day at bedtime. Your physician might alter your dose as wanted and tolerated. Higher doses could also be given in evenly divided parts through the day. However, the dose is normally no more than 250 mg per day.
      • Children 10 years of age and older: At first, 25 mg as soon as a day at bedtime. Your physician might alter your dose as wanted and tolerated. Higher doses could also be given in evenly divided parts through the day. However, the dose is normally no more than 200 mg per day.
      • Children youthful than 10 years of age: Use and dose have to be decided by your physician.

Missed Dosage

If you miss a dose of this medication, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

Anafranil Storage

  1. Store the drugs in a closed container at room temperature, away from warmth, moisture, and direct gentle. Keep from freezing.
  2. Keep out of the attain of youngsters.
  3. Do not hold outdated medication or medication now not wanted.
  4. Ask your healthcare skilled how you must eliminate any medication you don’t use.

Clomipramine Precautions

It is essential that your physician verify your or your kid’s progress at common visits to permit for modifications in your dose and to verify this medication is working correctly. Blood and urine checks could also be wanted to verify for negative effects.

Anafranil might trigger some individuals to be agitated, irritable, or show different irregular behaviors. It can also trigger some kids, youngsters, and younger adults to have suicidal ideas and tendencies or to develop into extra depressed. Some individuals might have bother sleeping, get upset simply, have an enormous enhance in power, or begin to act reckless. Also inform the physician in the event you or your youngster have sudden or sturdy emotions, akin to feeling nervous, indignant, stressed, violent, or scared. If you, or your caregiver discover any of those negative effects, inform your physician immediately. Let the physician know in the event you, your youngster, or anybody in your loved ones has bipolar dysfunction (manic-depressive) or has tried to commit suicide.

Do not use Anafranil with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], linezolid (Zyvox®), phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not begin utilizing clomipramine through the 2 weeks after you cease an MAO inhibitor. Wait for two weeks after stopping Anafranil earlier than you begin utilizing an MAO inhibitor. If you’re taking them collectively or don’t wait 2 weeks, you could develop:

  • confusion
  • agitation
  • restlessness
  • abdomen or bowel signs
  • a sudden excessive physique temperature
  • a particularly hypertension
  • extreme convulsions (seizures)

Clomipramine Side Effects

Along with its wanted results, a drugs might trigger some negative effects. Although not all of those negative effects might happen, in the event that they do happen they could want medical consideration. Check along with your physician instantly if any of the next negative effects happen:

  • Bladder ache
  • bloody or cloudy urine
  • blurred imaginative and prescient
  • physique aches or ache
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling emotions
  • confusion
  • troublesome, burning, or painful urination
  • dizziness, faintness, or lightheadedness when getting up all of a sudden from a mendacity or sitting place
  • extreme muscle tone
  • worry or nervousness
  • feeling unhappy or empty
  • fever

Other negative effects not listed can also happen in some sufferers. If you discover some other results, verify along with your healthcare skilled. Call your physician for medical recommendation about negative effects.


Information concerning psychotic disorders, included within the review of Clomipramine, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.


⚠Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.

Frequently asked questions

  • What is Clomipramine Anafranil?

    Anafranil is a drug used to treat obsessive-compulsive disorder (OCD). This is a nervous condition where a person has recurring thoughts or ideas or does repetitive things because they are anxious. 

  • What to do if you miss a dose?

    If you miss a dose of Clomipramine, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  • What if u take too much Anafranil?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  • How to store Clomipramine?

    Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. 

  • What Should I Avoid While Taking Clomipramine?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Anafranil. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  • What are the side effects of Clomipramine Anafranil?

    The most common side effects are dizziness, dry mouth, drowsiness, constipation, stomach upset, nausea, vomiting, sweating etc. Anxiety symptoms may temporarily worsen when you first start using Clomipramine. 

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Last Updated on October 23, 2021 by

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