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Active Ingredient: Quetiapine
Brand Name: Seroquel

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What is Seroquel?

Seroquel is an oral antipsychotic (neuroleptic) medication used for treating schizophrenia and acute manic episodes associated with bipolar I disorder. It shows more affinity with serotonin receptors (5-HT2) than with dopamine receptors D1 and D2 in the brain. It also active toward the alpha 1 adrenoreceptor and less active toward alpha 2 adrenoreceptor.

  • Duration of binding with 5-HT2-serotonin and D2 dopamine receptors is less than 12 hours. Mechanism of Quetiapine action is unknown. Though it is supposed that the therapeutic effect is mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) receptor antagonism. This medication is used to treat acute and chronic psychosis also ones in patients with schizophrenia.

Why is Quetiapine so effective?

It works by altering the levels of certain chemical messengers called neurotransmitters in your brain, in particular, serotonin and dopamine. Although it has a sedative effect, quetiapine isn’t recommended for insomnia.

How does Seroquel make you feel?

Quetiapine works by attaching to the brain’s dopamine receptors and altering serotonin levels. Short-term effects include feeling sleepy, a dry mouth, dizziness and low blood pressure when you stand up. These effects lasts about six hours.

What can you use Quetiapine for?

This medication is used to treat certain mental/mood conditions (such as schizophrenia, bipolar disorder, sudden episodes of mania or depression associated with bipolar disorder). Quetiapine is known as an anti-psychotic drug (atypical type).


If the psychotic episode is over, you will usually need to continue taking this medicine for a long time. Otherwise the risk of a new psychosis (relapse) is too high. The doctor will sometimes reduce the dose during this period.

If you have had a psychosis for the first time, you will usually need to take this medicine for 1 or 2 years after your recovery before you can try to stop. Only in exceptional cases, if you have recovered very quickly, can you try to stop six months after recovery. This must be done under proper supervision and the risk of relapse is still greater. If you have had a psychosis before, you usually have to continue taking an antipsychotic for the rest of your life.

Mania and depression

When the worst of the agitation symptoms have subsided, the doctor may recommend slowly tapering the use of quetiapine. Lithium or valproic acid, or the medication for depression should then usually continue to be used. Sometimes the doctor may recommend continuing quetiapine to prevent a new mania or depression.


Quetiapine is usually used for several years by people with severe agitation, aggression or anxiety, such as people with dementia, mentally retarded people and people with autism. The dosage is usually reduced, however, as symptoms subside.

Obsessive-compulsive disorder

If the drug works well, you usually need to keep taking it for several years.

Does Seroquel help with paranoia?

Quetiapine/Seroquel® helps moderate paranoia, delusions and hallucinations. It is less likely to cause side effects like involuntary movements or stiffness. Because of this, may be a good option, but rarely may cause more confusion for those suffering from Parkinson’s or Lewy Body dementia.

How do I use Quetiapine?

Seroquel should be taken twice or thrice daily with or without food with a full glass of water. Swallow the tablet whole, do not crush or chew an extended-release tablet. A daily dose of four first therapeutic days is 50 mg, 100 mg (second day), 200 mg (third day), 300 mg (fourth day). Starting from the fourth day the dosage should be adjusted to the level of effective one (which can reach 750 mg daily). In patients with liver or kidney failure, the initial dose is 25 mg/day increased gradually by 25-50 mg till the effective dose is reached. Take exactly as prescribed by your physician and do not exceed the recommended dose.

Quetiapine tablets:

  • Swallow the tablet whole with water without chewing.
  • Extended-release tablets (identified by XR): swallow the tablet whole without chewing. These tablets should not be taken with food. Take these tablets at least 1 hour before eating.

Is 25 mg of Quetiapine enough?

The usual therapeutic dose range for the approved indications is 400–800 mg/day. The 25 mg dose has no uses that are evidence based other than for dose titration in older patients.

What does 300 mg of Seroquel do?

Quetiapine 300 mg tablets are white, capsule-shaped and engraved with SEROQUEL on one side and 300 on the other side. Seroquel is indicated for: treatment of schizophrenia. – For the prevention of recurrence of manic or depressed episodes in patients with bipolar disorder who previously responded to quetiapine treatment.

How long before bed should I take Quetiapine?

Because it is an extended-release medicine, the dose should be taken once a day, 3-4 hours before bedtime. It is very important to follow your health care professional’s directions when you take this drug.

Missed dose

Take the missed dose as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your schedule. Do not double dose this medication to make up the missed dose.


If you took too much of Seroquel you may experience such symptoms: extreme drowsiness, fast heart rate, feeling light-headed, or fainting. If you suppose that took too much for this medication seeks for immediate medical help.

Possible side effects

Seroquel antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug. Most common and frequent adverse effects of Seroquel are headache, agitation, dizziness, drowsiness, weight gain and stomach upset. Long term use of this medication may cause irreversible tardive dyskinesia, a neurologic disease which consists of involuntary movements of the jaw, lips, and tongue.

  • Other side effects concern nervous system: headache, anxiety, fatigue, hostility, agitation, insomnia, tremors, convulsions, depression, neuroleptic malignant syndrome (hyperthermia, muscle rigidity, altered mental status, the lability of the autonomic nervous system increased activity of CPK).
  • Adverse effects of Quetiapine for cardiovascular system are tachycardia, prolongation of the interval QT.
  • Dryness of the oral mucosa, nausea, vomiting, abdominal pain, diarrhoea or constipation, increased activity of “liver” transaminases, pharyngitis, rhinitis may also appear. Allergic reactions such as skin rash, eosinophilia are also not excluded.


This medication affects the ability to the high concentration of attention so it may affect your ability to drive a car or operate machinery. Before to take Seroquel to notify your doctor if you have liver or kidney disease, heart disease, high blood pressure, heart rhythm problems, heart attack or stroke in history, a history of low white blood cell counts, a thyroid disorder, high cholesterol or triglycerides, a personal or family history of diabetes, trouble swallowing, as you may need your dosage to be adjusted or pass special safety tests for this medication.

Is it hard to get off Seroquel?

If you stop taking Quetiapine abruptly, it may be important to know that there have been rare reports of mild or severe withdrawal symptoms. Some of these symptoms may include nausea, vomiting, or restlessness. In rare cases, a patient might experience abnormal movements known as withdrawal dyskinesia.

What happens if you suddenly stop taking Quetiapine?

If you suddenly stop taking quetiapine, you may experience withdrawal symptoms such as nausea, vomiting, and difficulty falling asleep or staying asleep. Your doctor will probably want to decrease your dose gradually.

How much weight do you gain on Seroquel?

In patients treated with < 200 mg/day of quetiapine, mean weight gain was 1.54 kg, compared with 4.08 kg for 200 to 399 mg/day, 1.89 kg for 400 to 599 mg/day, and 3.57 kg for >or= 600 mg/day; median weight gain was 0.95 kg, 3.40 kg, 2.00 kg, and 3.34 kg, respectively.

Can Seroquel cause nightmares?

Quetiapine can also cause sleep-talking, sleep-walking, and some people have done other activities while they were asleep, like eating. You might also have strange dreams or nightmares. Talk to your doctor if any of this worries you.

Does quetiapine cause alopecia?

Alopecia has previously been reported with the atypical antipsychotic medicines olanzapine and risperidone, but has not been described with quetiapine. Case reports of alopecia associated with quetiapine reported to the New Zealand Intensive Medicines Monitoring Programme were reviewed.


Hypersensitivity, pregnancy, breastfeeding. Seroquel should be used with cautiousness in patients with hypotension, epilepsy and epileptic seizures in history. Seroquel may contribute to the development of heart failure, pneumonia, sudden death, in older adults with conditions caused by dementia.

What can you not do when you take Seroquel?

Do not drive or operate machinery or perform hazardous tasks if Seroquel makes you sleepy. Talk to your doctor if you feel that your mood is worsening or you feel agitated or are having suicide-related thoughts. Avoid alcohol while taking Seroquel and keep hydrated. Avoid over-exercising.

Drug interactions

Phenytoin (Dilantin) and thioridazine (Mellaril) decrease absorption of Seroquel in intestines and decrease its effects. Seroquel interacts with narcotic pain relievers, medications for hypertension interact with and their activities add oxycodone and acetaminophen (Percocet, Roxicet, Tylox, Endocet), barbiturates, alprazolam (Xanax), clonazepam (Klonopin), ethanol, prazosin (Minipress) and terazosin (Hytrin).

Toxicity of Quetiapine may increase if it is co-administered with the drugs able to influence work of cytochrome P450 which is responsible for the metabolism of Seroquel, these drugs are ketoconazole (Nizoral), itraconazole (Sporanox), fluconazole (Diflucan), erythromycin, clarithromycin (Biaxin), nefazodone (Serzone), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem, Tiazac, Dilacor).


Store Seroquel at room temperature, 15-30 C (59-86 F) away from sunlight, moisture, children and pets.

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On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.

Frequently asked questions

What is Seroquel?

Quetiapine belongs to the atypical antipsychotics. It reduces in the brain the effect of naturally occurring substances, mainly dopamine. This reduces psychosis and agitation. Doctors prescribe it for psychosis, schizophrenia, depression and agitation. Also when you are too happy and have too much energy which causes you to not sleep enough, for example (mania). Doctors may also prescribe it for obsessive-compulsive disorder. Look at all the different types of Seroquel here.

What should i do if i miss a dose?

It is important to take this medicine consistently. If you do forget a dose:

– If you are taking this medicine once a day: will it be more than 8 hours before you take the next dose as normal? Then take the forgotten dose. Will it be less than 8 hours? Then skip the forgotten dose.
– If you are taking this medicine twice a day: will it be more than 4 hours before you take the next dose as normal? Then take the forgotten dose. Will it be less than 4 hours? Then skip the forgotten dose.

Can i just stop taking this medicine?

No, many people develop psychosis again after stopping an antipsychotic. It is therefore important to consult with your doctor beforehand. In some psychoses the risk of a new psychosis is not so great, in others it is.

If you are going to stop, taper off slowly over a period of at least 4 weeks. If you stop gradually, you have less chance of immediately suffering a new psychosis. It also prevents withdrawal symptoms, such as sweating, nausea, loss of appetite, diarrhea, anxiety, sleeplessness, restlessness, runny nose, muscle pain and strange sensations, such as jitters. Look at all the different types of Seroquel here.

What are the side effects of Quetiapine?

The main side effects that may occur after taking seroquel are, drowsiness dizziness, dry eyes, blurred vision, gastrointestinal symptoms, change in thoughts and behavior and unusual muscle movements.

– Because of the relaxing effect of quetiapine, you may have trouble getting muscles to move. Restlessness or stiffness of the muscles are also side effects of quetiapine.
– Weight gain is also one of the side effects. This is due to an increase in appetite and altered metabolism. Consult your doctor or a dietitian if this bothers you a lot.
– Difficulty having sex is also a side effect. In men: difficulty getting an erection. In women: more difficult to achieve an orgasm. In men and women: less desire to have sex

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Last Updated on November 19, 2021 by Toni El Clikos

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