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What is Donepezil
Donepezil is an irregular antipsychotic medicine. Blocks dopamine receptors of CNS as well as conflicts dopamine button in basic gangliya as well as in limbic a component of neoncephalon. It is taken at hypersensitivity, disorders of hemopoietic system (along with in anamnesis), alcoholic as well as harmful psychosis, myasthenia, comas.
Aricept Drug Uses
Donepezil is used to treat dementia (memory loss and mental changes) associated with mild, moderate, or severe Alzheimer’s disease. Donepezil will not cure Alzheimer’s disease, and it will not stop the disease from getting worse. However, it can improve thinking ability in some patients.
What Should You Discuss To Your Doctor Before Using This Medicine
- Anesthesia: ARICEPT, as a cholinesterase inhibitor, is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia.
- Cardiovascular Conditions: Because of their pharmacological action, cholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes. This effect may manifest as bradycardia or heart block in patients both with and without known underlying cardiac conduction abnormalities. Syncopal episodes have been reported in association with the use of ARICEPT.
- Nausea And Vomiting: ARICEPT, as a predictable consequence of its pharmacological properties, has been shown to produce diarrhea, nausea, and vomiting. These effects, when they occur, appear more frequently with the 10 mg/day dose than with the 5 mg/day dose, and more frequently with the 23 mg dose than with the 10 mg dose. Specifically, in a controlled trial that compared a dose of 23 mg/day to 10 mg/day in patients who had been treated with donepezil 10 mg/day for at least three months, the incidence of nausea in the 23 mg group was markedly greater than in the patients who continued on 10 mg/day (11.8% vs. 3.4%, respectively), and the incidence of vomiting in the 23 mg group was markedly greater than in the 10 mg group (9.2% vs. 2.5%, respectively). The percent of patients who discontinued treatment due to vomiting in the 23 mg group was markedly higher than in the 10 mg group (2.9% vs. 0.4%, respectively).
- Weight Loss: Weight loss was reported as an adverse reaction in 4.7% of patients assigned to ARICEPT in a dose of 23 mg/day compared to 2.5% of patients assigned to 10 mg/day. Compared to their baseline weights, 8.4% of patients taking 23 mg/day were found to have a weight decrease of ≥7% by the end of the study, while 4.9% of patients taking 10 mg/day were found to have weight loss of ≥7% at the end of the study.
- Genitourinary Conditions: Although not observed in clinical trials of ARICEPT, cholinomimetics may cause bladder outflow obstruction.
- Neurological Conditions: Seizures: Cholinomimetics are believed to have some potential to cause generalized convulsions. However, seizure activity also may be a manifestation of Alzheimer’s disease.
- Pulmonary Conditions: Because of their cholinomimetic actions, cholinesterase inhibitors should be prescribed with care to patients with a history of asthma or obstructive pulmonary disease.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
- Bitter Orange
- Grapefruit Juice
Other Medical Problems Aricept
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Lung disease
- Peptic ulcers,
- Urinary tract blockage or difficult urination
- Heart problems
- Liver disease
- Low body weight (below 50 kilograms or 110 pounds)
Take this medicine exactly as directed by your doctor in order to improve your condition as much as possible. Do not take more of it or less of it, and do not take it more or less often than your doctor ordered.
Donepezil should be taken at bedtime unless otherwise directed by your doctor. It may be taken with or without food, on a full or empty stomach. Swallow the tablet whole. Do not crush, break, or chew it.
For patients using the oral disintegrating tablet form of this medicine:
- Make sure your hands are dry.
- Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
- Immediately place the tablet on top of the tongue.
- Do not swallow the tablet whole. The tablet will dissolve in seconds, and you may swallow it with your saliva. You should drink a glass of water after the tablet has dissolved.
For patients taking the oral solution form of this medicine:
- Shake the bottle well before measuring the dose.
- Use a specially marked measuring spoon, a plastic syringe, or a small marked measuring cup to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.
- If your dose is 5 mg, you should take 5 mL of this medicine.
- If your dose is 10 mg, you should take 10 mL of this medicine.
The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage forms (oral disintegrating tablets, oral solution, and tablets):
- For mild to moderate Alzheimer’s disease:
- Adults—5 milligrams (mg) taken at bedtime. Your doctor may increase your dose as needed. However, the dose usually is not more than 10 mg per day.
- Children—Use and dose must be determined by your doctor.
- For moderate to severe Alzheimer’s disease:
- Adults—10 milligrams (mg) taken at bedtime. Your doctor may increase your dose as needed. However, the dose usually is not more than 23 mg per day.
- Children—Use and dose must be determined by your doctor.
- For mild to moderate Alzheimer’s disease:
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
- Ask your healthcare professional how you should dispose of any medicine you do not use.
- Keep out of the reach of children.
- Do not keep outdated medicine or medicine no longer needed.
It is important that your doctor check your progress at regular visits. This is necessary to allow dose adjustments and to reduce any unwanted effects. Before you have any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine. Taking donepezil together with certain medicines that are used during surgery or dental or emergency treatments may increase the effects of those medicines and cause unwanted effects.
This medicine may cause some people to become dizzy or drowsy, to have blurred vision, or to have problems with clumsiness or unsteadiness. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert, well-coordinated, and able to see clearly.
Some people who have used this medicine developed problems such as nausea, severe vomiting, loss of appetite, diarrhea, and weight loss. Talk with your doctor before using this medicine if you have any concerns.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur:
- loss of appetite
- muscle cramps
- trouble in sleeping
- unusual tiredness or weakness
Other negative effects not listed can also happen in some sufferers. If you discover some other results, verify along with your healthcare skilled. Call your physician for medical recommendation about negative effects.
Information concerning psychotic disorders, included within the review of Donepezil, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.
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On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.
℞ Frequently asked questions
What is Donepezil Aricept?
Donepezil contains active ingredient donepezil hydrochloride which is an inhibitor of the enzyme acetylcholinesterase and hereby blocks disintegration of acetylcholine, which is responsible for the transfer of excitation in the central nervous system. Donepezil slows progress of dementia caused by Alzheimer's disease.
What to do if you miss a dose?
If you miss a dose of Donepezil, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.
What if u take too much Aricept?
If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.
How to store Donepezil?
Store at room temperature of 59-86 F (15-30 C) away from moisture and sunlight.
What Should I Avoid While Taking Donepezil?
Avoid consuming alcohol or utilizing unlawful medicine when you are taking Aricept. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.
What are the side effects of Donepezil Aricept?
This medication is usually well tolerated and adverse reactions are not expected. Most frequent side effects include pain or tightness in the chest or throat, tingling, flushing, weakness, dizziness, abdominal discomfort, sweating, nasal irritation, and injection site reactions.
What are the Contraindication?
Aricept cannot be used in the patients with hypersensitivity to donepezil and to derivatives of piperidine.
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Last Updated on October 26, 2021 by Toni El Clikos