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Active ingredient: Modafinil

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What is Provigil

Provigil is an irregular antipsychotic medicine. Blocks dopamine receptors of CNS as well as conflicts dopamine button in basic gangliya as well as in limbic a component of neoncephalon. It is taken at Hypersensitivity, disorders of hemopoietic system (along with in anamnesis), alcoholic as well as harmful psychosis, myasthenia, comas.

Provigil Drug Uses

Provigil is used to assist individuals who have narcolepsy, obstructive sleep apnea/hypopnea syndrome (OSAHS), or shift work sleep problem (SWSD) to remain awake through the day. Provigil doesn’t treatment these situations and can solely work so long as you proceed to take it.

What Should You Discuss To Your Doctor Before Using This Medicine

  1. Diagnosis of Sleep Disorders: Provigil should be used only in patients who have had a complete evaluation of their excessive sleepiness, and in whom a diagnosis of either narcolepsy, OSA, and/or SWD has been made in accordance with ICSD or DSM diagnostic criteria. Such an evaluation usually consists of a complete history and physical examination, and it may be supplemented with testing in a laboratory setting. Some patients may have more than one sleep disorder contributing to their excessive sleepiness (e.g., OSA and SWD coincident in the same patient).
  2. General: Although Provigil has not been shown to produce functional impairment, any drug affecting the CNS may alter judgment, thinking or motor skills. Patients should be cautioned about operating an automobile or other hazardous machinery until they are reasonably certain that Provigil therapy will not adversely affect their ability to engage in such activities.
  3. CPAP Use in Patients with OSA: In OSA, Provigil is indicated as an adjunct to standard treatment(s) for the underlying obstruction. If continuous positive airway pressure (CPAP) is the treatment of choice for a patient, a maximal effort to treat with CPAP for an adequate period of time should be made prior to initiating Provigil. If Provigil is used adjunctively with CPAP, the encouragement of and periodic assessment of CPAP compliance is necessary.
  4. Cardiovascular System: Provigil has not been evaluated in patients with a recent history of myocardial infarction or unstable angina, and such patients should be treated with caution.
  5. Patients Using Steroidal Contraceptives: The effectiveness of steroidal contraceptives may be reduced when used with Provigil tablets and for one month after discontinuation of therapy. Alternative or concomitant methods of contraception are recommended for patients treated with Provigil tablets, and for one month after discontinuation of Provigil.
  6. Patients Using Cyclosporine: The blood levels of cyclosporine may be reduced when used with Provigil. Monitoring of circulating cyclosporine concentrations and appropriate dosage adjustment for cyclosporine should be considered when these drugs are used concomitantly.
  7. Patients with Severe Hepatic Impairment: In patients with severe hepatic impairment, with or without cirrhosis, Provigil should be administered at a reduced dose.
  8. Patients with Severe Renal Impairment: There is inadequate information to determine safety and efficacy of dosing in patients with severe renal impairment. (For pharmacokinetics in renal impairment.
  9. Elderly Patients: In elderly patients, elimination of Provigil and its metabolites may be reduced as a consequence of aging. Therefore, consideration should be given to the use of lower doses in this population.

Provigil Drug Interactions

Although sure medicines shouldn’t be used collectively in any respect, in different instances two totally different medicines could also be used collectively even when an interplay may happen. In these instances, your physician might need to change the dose, or different precautions could also be mandatory. When you take this medication, it’s particularly vital that your healthcare skilled know if you’re taking any of the medicines listed under. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Using this medication with any of the next medicines is normally not really helpful, however could also be required in some instances. If each medicines are prescribed collectively, your physician might change the dose or how typically you utilize one or each of the medicines.

  • Alfentanil
  • Amiodarone
  • Avapritinib
  • Axitinib
  • Benzhydrocodone
  • Brigatinib
  • Buprenorphine
  • Capmatinib
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Cobimetinib
  • Codeine

Other Interactions

Certain medicines shouldn’t be used at or across the time of consuming meals or consuming sure kinds of meals since interactions might happen. Using alcohol or tobacco with sure medicines may trigger interactions to happen. Discuss along with your healthcare skilled using your medication with meals, alcohol, or tobacco.

Other Medical Problems of Provigil

The presence of different medical issues might have a side effect on using this medication. Make certain you inform your physician if in case you have every other medical issues, particularly:

Provigil Proper Usage

Take this medication solely as directed by your physician. Do not take extra of it, don’t take it extra typically, and don’t take it for an extended time than your physician ordered. If an excessive amount of is taken, it could change into habit-forming.

  1. This medication comes with a Medication Guide. It is essential that you simply learn and perceive this info. Be certain to ask your physician about something you don’t perceive.
  2. This medication doesn’t take the place of getting sufficient sleep. It shouldn’t be used for infrequent sleepiness that has not been recognized as narcolepsy, sleep apnea, or shift work sleep issues. Ask your physician for recommendation about good sleep habits.
  3. If you’ve sleep apnea and use a steady constructive airway stress (CPAP) machine at evening, proceed utilizing this machine with Provigil.
  4. Take this medication on the similar time every day. Do not change the time of day you are taking Provigil with out speaking first along with your physician.
  5. You might take this medication with or with out meals.

Provigil Dosage

The dose of this medication can be totally different for various sufferers. Follow your physician’s orders or the instructions on the label. The following info consists of solely the common doses of this medication. If your dose is totally different, don’t change it until your physician tells you to take action.

The quantity of medication that you simply take will depend on the energy of the medication. Also, the variety of doses you are taking every day, the time allowed between doses, and the size of time you are taking the medication rely on the medical drawback for which you might be utilizing the medication.

  • For oral dosage kind (tablets):
    • For narcolepsy or obstructive sleep apnea/hypopnea syndrome:
      • Adults and youngsters 17 years of age and older: 200 milligrams (mg) as soon as a day, within the morning. Your physician might enhance your dose as wanted.
      • Teenagers and kids youthful than 17 years of age: Use and dose should be decided by your physician.
    • For shift work sleep problem:
      • Adults and youngsters 17 years of age and older: 200 milligrams (mg) one hour earlier than you start working.
      • Teenagers and kids youthful than 17 years of age: Use and dose should be decided by your physician.

Missed dosage

If you miss a dose of this medication, skip the missed dose and return to your common dosing schedule. Do not double doses. If you miss a dose of Provigil and also you bear in mind it earlier than 12:00 midday the identical day, take the missed dose as quickly as attainable.

Provigil Precautions

Your physician ought to examine your progress at common visits to make it possible for this medication is working correctly. Your blood stress might have to be checked extra typically whereas taking this medication.

It is vital to inform your physician if you happen to change into pregnant. Your physician might want you to hitch a being pregnant registry for sufferers taking this medication.

Serious pores and skin reactions can happen with this medication. Stop utilizing this medication and examine along with your physician instantly if in case you have blistering, peeling, or loosening of the pores and skin; pink pores and skin lesions; extreme pimples or pores and skin rash; sores or ulcers on the pores and skin; or fever or chills if you are utilizing this medication.

This medication might trigger you to have a critical sort of allergic response known as anaphylaxis. Anaphylaxis might be life-threatening and requires instant medical consideration. Stop taking this medication and name your physician instantly if in case you have a pores and skin rash; itching; hives; hoarseness; bother respiratory; bother swallowing; or any swelling of your fingers, face, or mouth if you are utilizing this medication.

This medication might trigger critical allergic reactions affecting a number of physique organs (e.g., coronary heart, liver, or blood cells). Stop utilizing this medication and examine along with your physician instantly if in case you have the next signs:

  • chest ache or discomfort
  • fever and chills
  • darkish urine
  • headache
  • rash
  • abdomen ache
  • uncommon tiredness
  • uncommon bleeding or bruising
  • yellow eyes or pores and skin

Provigil Storage

  1. Store the medication in a closed container at room temperature, away from warmth, moisture, and direct gentle. Keep from freezing.
  2. Keep out of the attain of youngsters.
  3. Do not preserve outdated medication or medication now not wanted.
  4. Ask your healthcare skilled how you need to eliminate any medication you don’t use.

Provigil Side Effects

Along with its wanted results, a medication might trigger some negative effects. Although not all of those uncomfortable side effects might happen, in the event that they do happen they might want medical consideration.

Check along with your physician instantly if any of the next uncomfortable side effects happen:

  • Black, tarry stools
  • blurred imaginative and prescient or different imaginative and prescient adjustments
  • chest ache
  • chills or fever
  • clumsiness or unsteadiness
  • confusion
  • dizziness or fainting
  • elevated thirst and urination
  • psychological despair
  • issues with reminiscence

Other negative effects not listed can also happen in some sufferers. If you discover some other results, verify along with your healthcare skilled. Call your physician for medical recommendation about negative effects.

Symptoms of Overdose

  • Agitation or pleasure
  • quick or pounding heartbeat
  • elevated blood stress
  • bother with sleeping


Information concerning psychotic disorders, included within the review of Provigil, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.

⚠Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.

Frequently asked questions

  • What is Provigil?

    Provigil may help treat your narcolepsy and reduce the likelihood that you will have sleep attacks. It has also been used to treat shift work sleep disorder, and sleep apnoea.

  • What to do if you miss a dose?

    If you miss a dose of Provigil, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  • What if u take too much Provigil?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  • How to store Provigil?

    Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. 

  • What Should I Avoid While Taking Provigil?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Provigil. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  • What are the side effects of Provigil?

    They may include dizziness, feeling irritable, sleepiness, extreme tiredness or difficulty sleeping (insomnia).

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Last Updated on October 19, 2021 by Toni El Clikos

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