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What is Prednisolone?

Prednisolone is a synthetic analogue of the hormones cortisone and hydrocortisone. The drug causes significant anti-inflammatory, antiallergic, anti exudative, antishock, anti-toxic effects. Anti-inflammatory effect of prednisolone is achieved mainly associated with cytosolic glucocorticosteroid receptors. The complex between the hormone and the receptor penetrates into the nucleus of the target skin cell enhances expression of the genes that code synthesis of lipoproteins, the substances which inhibit phospholipase A2 and reduce the synthesis of metabolic products of arachidonic acid cyclic known to participate in inflammatory reaction.

  • Antiallergic effect of the drug is explained by its ability to decrease the number of basophils and inhibit synthesis and secretion of biologically active substances. Prednisolone is used to treat many different conditions such as allergic disorders, collagenosis (skin conditions), infectious nonspecific polyarthritis, psoriasis, lupus, ulcerative colitis, bronchial asthma, acute lymphoblastic and myeloid leukaemia, neurodermatitis, eczema, Addison disease (decreased adrenal function), and many others.

Dosage and direction

Individual dosing is necessary for each condition. Acute conditions and initial dose are usually 5-60 mg a day. The maintenance dose is usually 5-10 mg a day. Do not take more of Prednisolone than it was prescribed to you. Follow all recommendations of your doctor.


Inform your doctor about all diseases you have and especially about liver or kidney disease, a thyroid disorder, diabetes, tuberculosis, malaria, myasthenia gravis, stomach ulcerations, glaucoma, mental illness as use of the steroid may influence these conditions. Steroid medications are known to weaken the immune system, so it may become easier for you to be infected anew or your existing infection may worsen. Inform your doctor if you have been sick recently with infection. Avoid sick people. Inform your doctor if you contact with people with chickenpox or measles because these diseases are maybe fatally dangerous to people treated by steroids. You should not be vaccinated by? live? vaccines during treatment with Prednisolone. Do not interrupt treatment with Prednisolone suddenly to avoid unpleasant withdrawal symptoms. Inform your doctor about your pregnancy.


This medication cannot be used in the patients with severe hypertension, diabetes and Itsenko-Cushing syndrome, in pregnant women, severe circulatory failure, acute endocarditis (inflammation of the inner cavities of the heart), psychosis, nephritis, osteoporosis, stomach and duodenal ulcers, recently surgery, syphilis, the active form of tuberculosis, in elderly patients.

Side effects

This medication may be a reason of obesity, hirsutism (excess body hair growth in women), acne, menstrual disorders, osteoporosis, Itsenko-Cushing syndrome (obesity, decreased sexual function, bone fragility), gastrointestinal ulceration, ulcer perforation, hemorrhagic pancreatitis, hyperglycemia (high blood sugar), increase in blood clotting, mental disorders. Withdrawal symptoms are possible, especially after long treatment. Other side effects which should be informed about to your doctor if they worsen are changes in vision, depression, seizures, bloody or tarry stools, low potassium (increased urination, extreme thirst, uneven heart rate), hypertension.

Drug interaction

Concomitant use of Prednisolone and anti-diabetic and anticoagulant drugs requires correction of the doses. In patients with Addison disease concomitant use of Prednisolone and barbiturates should be exercised with cautiousness.

Missed dose

If you forgot to take your dose in time, contact your doctor or a health care advisor.


This medication is not likely to cause life-threatening symptoms. Dangerous conditions may be caused by prolonged use of the medication: easy bruising, thinning skin, body fat located in the back, face, neck, and waist, acne or facial hair growth, impotence, menstrual problems.


Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.

Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.

Frequently asked questions

  • What is Prednisolone?

    Prednisolone is an adrenal cortex hormone, also called a corticosteroid. Adrenal cortex hormones inhibit inflammation and hypersensitivity reactions. They are also needed to release and store energy, minerals and salts. Look at all the different types of Prednisolone here.

  • What to do if you miss a dose?

    Ask your doctor what to do if you forget a dose. Usually the advice is as follows:

    – If you are taking this medicine once a day: will it be more than eight hours before you take the next dose? Then take the forgotten dose. Will it be less than eight hours? Skip the forgotten dose.
    – If you are taking this medicine several times a day, take the forgotten dose as soon as possible. Is it already time for the next dose? Ask your doctor what to do in that case. In some cases you can take both doses at the same time. This depends mainly on how high the dose is that you are taking
    – If you take this medicine once every 2 days: take the forgotten dose the next morning. If you do not find out until after 2 days when you need to take the next dose, skip the forgotten dose. Then skip the forgotten dose.

  • Can i suddenly stop with this medicine?

    Have you been taking this medicine for a long time in a row and suddenly stop? If so, you may experience severe symptoms such as headaches, muscle aches, tremors, dizziness, heart palpitations, diarrhea, nausea, weakness, and feeling lame. These symptoms occur because your own adrenal cortex has started to produce fewer hormones during use. After all, there is already enough adrenal cortex hormone in the body. If you stop suddenly, the adrenal cortex cannot start producing the hormones all at once. Look at all the different types of Prednisolone here.

  • What are other types of diseases where this medicine is used for?

    In inflammatory diseases, it is used in different ways: in a high dose for a few days to weeks (shock treatment) and in a lower dose for several months (long-term treatment). Doctors usually prescribe it as a shock treatment. Prednisolone is also used to counteract rejection reactions after organ transplants and as part of treatment for cancer. It is also used to supplement a shortage of the body's own adrenal hormones (as in the adrenal diseases Addison's disease, Cushing's disease and adrenogenital syndrome). When used in this way it is called substitution therapy.

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Last Updated on September 14, 2021 by Toni El Clikos

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