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Active Ingredient: Ondansetron
Brand(s): Zofran

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What is Ondansetron

Ondansetron is an irregular antipsychotic medicine. Blocks dopamine receptors of CNS as well as conflicts dopamine button in basic gangliya as well as in limbic a component of neoncephalon. It is taken at hypersensitivity, disorders of hemopoietic system (along with in anamnesis), alcoholic as well as harmful psychosis, myasthenia, comas.

Zofran Drug Uses

Ondansetron is used to stop the nausea and vomiting which will happen after remedy with most cancers medicines (chemotherapy or radiation), together with high-dose cisplatin. This medication can also be used to stop and deal with nausea and vomiting which will occur after surgical procedure.

What Should You Discuss To Your Doctor Before Using This Medicine

  1. Hypersensitivity Reactions: Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists. If hypersensitivity reactions occur, discontinue use of Ondansetron; treat promptly per standard of care and monitor until signs and symptoms resolve.

  2. QT Prolongation: Electrocardiogram (ECG) changes, including QT interval prolongation have been seen in patients receiving ondansetron. In addition, post marketing cases of Torsade de Pointes have been reported in patients using Ondansetron. Avoid Ondansetron in patients with congenital long QT syndrome. ECG monitoring is recommended in patients with electrolyte abnormalities, congestive heart failure, bradyarrhythmias, or patients taking other medicinal products that lead to QT prolongation.

  3. Serotonin Syndrome: The development of serotonin syndrome has been reported with 5-HT3 receptor antagonists alone. Most reports have been associated with concomitant use of serotonergic drugs (e.g., selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors, mirtazapine, fentanyl, lithium, tramadol, and intravenous methylene blue). Some of the reported cases were fatal. Serotonin syndrome occurring with overdose of Ondansetron alone has also been reported. The majority of reports of serotonin syndrome related to 5-HT3 receptor antagonist use occurred in a post-anesthesia care unit or an infusion center.

Ondansetron Drug Interactions

Although sure medicines shouldn’t be used collectively in any respect, in different instances two totally different medicines could also be used collectively even when an interplay may happen. In these instances, your physician might need to change the dose, or different precautions could also be mandatory. When you might be taking this medication, it’s particularly vital that your healthcare skilled know if you’re taking any of the medicines listed under. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Using this medication with any of the next medicines shouldn’t be really helpful. Your physician might determine to not deal with you with this medicine or change a number of the different medicines you are taking.

  • Apomorphine
  • Bepridil
  • Cisapride
  • Dronedarone
  • Fluconazole
  • Ketoconazole
  • Mesoridazine
  • Nelfinavir
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Other Interactions

Certain medicines shouldn’t be used at or across the time of consuming meals or consuming sure kinds of meals since interactions might happen. Using alcohol or tobacco with sure medicines may trigger interactions to happen. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Using this medication with any of the next is normally not really helpful, however could also be unavoidable in some instances. If used collectively, your physician might change the dose or how typically you utilize this medication, or offer you particular directions about using meals, alcohol, or tobacco.

  • Tobacco

Other Medical Problems Zofran

The presence of different medical issues might have a side effects on using this medication. Make certain you inform your physician if in case you have every other medical issues, particularly:

  • Bowel blockage
  • Gastric distension
  • Bradyarrhythmia
  • Congestive coronary heart failure
  • Electrolyte imbalance 

Proper Usage of Ondansetron

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

  • Make sure your hands are dry.
  • Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
  • Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

  • Make sure your hands are clean and dry before and after using this medicine.
  • Fold the pouch along the dotted line to expose the tear notch.
  • While still folded, tear the pouch carefully along the edge and remove the film out from the pouch.
  • Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole.
  • Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Ondansetron Dosage

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (oral disintegrating tablets, solution, or tablets):
    • For prevention of moderate nausea and vomiting after treatment with cancer medicines:
      • Adults, teenagers, and children 12 years of age: At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days.
      • Children 4 to 11 years of age: At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days.
      • Children younger than 4 years of age: Use and dose must be determined by your doctor.
    • For prevention of more severe nausea and vomiting after treatment with cancer medicines:
      • Adults, teenagers, and children 12 years of age: One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment.
      • Children younger than 12 years of age: Use and dose must be determined by your doctor.
    • For prevention of nausea and vomiting after radiation treatment:
      • Adults: At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours.
      • Children: Use and dose must be determined by your doctor.
    • For prevention of nausea and vomiting after surgery:
      • Adults: 16 milligrams (mg) one hour before anesthesia is given.
      • Children: Use and dose must be determined by your doctor.
  • For oral dosage form (soluble film):
    • For prevention of moderate nausea and vomiting after treatment with cancer medicines:
      • Adults, teenagers, and children 12 years of age: At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days.
      • Children 4 to 11 years of age: At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days.
      • Children younger than 4 years of age: Use and dose must be determined by your doctor.
    • For prevention of more severe nausea and vomiting after treatment with cancer medicines:
      • Adults: 24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film.
      • Children: Use and dose must be determined by your doctor.
    • For prevention of nausea and vomiting after radiation treatment:
      • Adults: One 8-milligram (mg) film three times a day.
      • Children: Use and dose must be determined by your doctor.
    • For prevention of nausea and vomiting after surgery:
      • Adults: 16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film.
      • Children: Use and dose must be determined by your doctor.

Missed Dosage

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose of this medicine, and you feel nauseated or you vomit, take the missed dose as soon as possible.

Zofran Storage

  1. Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.
  2. Keep out of the reach of children.
  3. Do not keep outdated medicine or medicine no longer needed.
  4. Ask your healthcare professional how you should dispose of any medicine you do not use.
  5. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
  6. Keep the unused soluble film in the foil pouch until you ready to use it.

Ondansetron Precautions

  • Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.
  • Do not use this medicine if you are receiving apomorphine (Apokyn®). Using these medicines together may increase risk for more serious problems.
  • This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
  • Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
  • Check with your doctor right away if you start to have pain or swelling in your stomach area. These may be signs of a serious stomach or bowel problem.
  • This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Ondansetron Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

  • Confusion
  • dizziness
  • fast heartbeat
  • fever
  • headache
  • shortness of breath
  • weakness

Other negative effects not listed can also happen in some sufferers. If you discover some other results, verify along with your healthcare skilled. Call your physician for medical recommendation about negative effects.

Disclaimer

Information concerning psychotic disorders, included within the review of Ondansetron, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.

 

⚠Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.


Frequently asked questions

  • What is Ondansetron Zofran?

    Zofran is a prescription medicine that has been licensed to prevent nausea and vomiting due to several causes. It is used for preventing nausea and vomiting associated with cancer chemotherapy or surgery.

  • What to do if you miss a dose?

    If you miss a dose of Zofran and are taking it regularly, you should take it as soon as you can remember it. If you miss for long time and it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at a time to compensate fro the missed dose.

  • What if u take too much Zofran?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  • How to store Ondansetron?

    Zofran should be stored at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). 

  • What Should I Avoid While Taking Ondansetron?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Zofran. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  • What are the side effects of Ondansetron Zofran?

    If you develop any sexual side effects while taking Zofran, be sure to talk with your healthcare provider.


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Last Updated on October 21, 2021 by Toni El Clikos

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