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What is Selegiline

Selegiline – irregular antipsychotic medicine. Blocks dopamine receptors of CNS as well as conflicts dopamine button in basic gangliya as well as in limbic a component of neoncephalon. It is taken at Hypersensitivity, disorders of hemopoietic system (along with in anamnesis), alcoholic as well as harmful psychosis, myasthenia, comas.

Selegiline Drug Uses

Selegiline is utilized in mixture with levodopa or levodopa and carbidopa mixture to deal with Parkinson’s illness (generally known as “shaking palsy” or “paralysis agitans”). This medication works to extend and lengthen the results of levodopa, and will assist to gradual the progress of Parkinson’s illness. This medication is obtainable solely along with your physician’s prescription.

What Should You Discuss To Your Doctor Before Using This Product

In deciding to make use of a drugs, the dangers of taking the drugs have to be weighed in opposition to the great it would do. This is a call you and your physician will make. For this medication, the next needs to be thought-about:

  1. Allergies: Tell your physician you probably have ever had any uncommon or allergic response to this medication or some other medicines. Also inform your well being care skilled you probably have some other kinds of allergy symptoms, akin to to meals, dyes, preservatives, or animals. For non-prescription merchandise, learn the label or package deal components rigorously.
  2. Pediatric: Appropriate research haven’t been carried out on the connection of age to the results of selegiline within the pediatric inhabitants. Safety and efficacy haven’t been established.
  3. Geriatric: Appropriate research carried out up to now haven’t demonstrated geriatric-specific issues that might restrict the usefulness of selegiline within the aged. However, aged sufferers usually tend to have negative effects (eg, excessive or low blood stress, orthostatic hypotension, uncommon drowsiness), which can require warning for sufferers receiving selegiline.
  4. Breastfeeding: There are not any sufficient research in ladies for figuring out toddler threat when utilizing this remedy throughout breastfeeding. Weigh the potential advantages in opposition to the potential dangers earlier than taking this remedy whereas breastfeeding.

Selegiline Drug Interactions

Although sure medicines shouldn’t be used collectively in any respect, in different circumstances two totally different medicines could also be used collectively even when an interplay would possibly happen. In these circumstances, your physician might need to change the dose, or different precautions could also be needed. When you’re taking this medication, it’s particularly essential that your healthcare skilled know if you’re taking any of the medicines listed beneath. The following interactions have been chosen on the idea of their potential significance and aren’t essentially all-inclusive.

Using this medication with any of the next medicines is just not advisable. Your physician might determine to not deal with you with this remedy or change a number of the different medicines you’re taking.

  • Amitriptyline
  • Amoxapine
  • Amphetamine
  • Apraclonidine
  • Atomoxetine
  • Benzphetamine
  • Brimonidine
  • Bupropion
  • Carbamazepine
  • Carbinoxamine
  • Citalopram
  • Clomipramine
  • Codeine

Other Interactions of Selegiline

Certain medicines shouldn’t be used at or across the time of consuming meals or consuming sure kinds of meals since interactions might happen. Using alcohol or tobacco with sure medicines can also trigger interactions to happen. The following interactions have been chosen on the idea of their potential significance and aren’t essentially all-inclusive.

Using this medication with any of the next is normally not advisable, however could also be unavoidable in some circumstances. If used collectively, your physician might change the dose or how usually you utilize this medication, or provide you with particular directions about using meals, alcohol, or tobacco.

  • Avocado
  • Bitter Orange
  • Tyramine Containing Food

Other Medical Problems of Selegiline Selegiline

The presence of different medical issues might have an effect on using this medication. Make positive you inform your physician you probably have some other medical issues, particularly:

  • Diarrhea or
  • Liver illness—Use with warning. May make these situations worse.
  • Kidney illness—Use with warning. The results could also be elevated due to slower elimination of the drugs from the physique.
  • Kidney illness, extreme—The extended-release tablets shouldn’t be utilized in sufferers with this situation.
  • Liver illness (brought on by Selegiline®), historical past of or
  • Mononucleosis (“mono”)—Should not be utilized in sufferers with these situations.
  • Phenylketonuria (PKU)—The chewable pill and oral suspension comprise phenylalanine, which might make this situation worse.

Selegiline Proper Usage

Take this medication solely as directed by your physician. Do not take extra of it, don’t take it extra usually, and don’t take it for an extended time than your physician ordered.

It is greatest to take the capsules or tablets within the morning throughout breakfast and lunch. You mustn’t use it with dinner as a result of you might have bother sleeping.

  • If you’re utilizing the disintegrating pill, ensure that your arms are dry earlier than you deal with the pill.
  • Do not open the blister pack that incorporates the pill till you’re able to take it.
  • Remove the pill from the blister pack by peeling again the foil, then taking the pill out.
  • Do not push the pill by the foil.
  • Do not break or cut up the pill.
  • Place the pill on the highest of your tongue, the place it would soften shortly.
  • Do not eat meals or drink liquids for five minutes earlier than or after taking this medication.
  • It is greatest to take this medication earlier than breakfast.

Selegiline Dosage

The dose of this medication shall be totally different for various sufferers. Follow your physician’s orders or the instructions on the label. The following data consists of solely the common doses of this medication. If your dose is totally different, don’t change it except your physician tells you to take action.

The quantity of drugs that you simply take relies on the power of the drugs. Also, the variety of doses you’re taking every day, the time allowed between doses, and the size of time you’re taking the drugs depend upon the medical downside for which you’re utilizing the drugs.

  • For Parkinson’s illness:
    • For oral dosage types (capsules or tablets):
      • Adults—5 milligrams (mg) two occasions a day, taken at breakfast and lunch. Your physician might alter your dose as wanted.
      • Children—Use and dose have to be decided by your physician.
    • For oral dosage kind (oral disintegrating tablets):
      • Adults—At first, 1.25 milligrams (mg) as soon as a day earlier than breakfast, for at the very least 6 weeks. After 6 weeks, your physician might enhance your dose to 2.5 mg as soon as a day.
      • Children—Use and dose have to be decided by your physician.

Missed dosage

If you miss a dose of this medication, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

More Information

It is essential that your physician verify your progress at common visits to permit for modifications in your dose. Blood checks could also be wanted to verify for any negative effects.

Do not take selegiline you probably have used narcotic ache medicines (together with meperidine, methadone, tramadol, Demerol®, Dolophine®, Ultram®) or an MAO inhibitor (MAOI) (eg, isocarboxazid, linezolid, phenelzine, tranylcypromine, Marplan®, Nardil®, Parnate®, Zyvox®) throughout the previous 14 days. If you do, you could develop agitation, confusion, restlessness, abdomen or intestinal signs, sudden excessive physique temperature, extraordinarily hypertension, or extreme seizures.

Do not take cyclobenzaprine, dextromethorphan (Robitussin®, Pediacare®), propoxyphene (Darvon®), or St. John’s wort if you are utilizing this medication. Using these medicines collectively could cause negative effects.

Selegiline might trigger a situation known as serotonin syndrome when used along with sure MAO inhibitors (eg, phenelzine, rasagiline, tranylcypromine) and medicines to deal with despair (eg, amitriptyline, doxepin, fluoxetine, fluvoxamine, nortriptyline, paroxetine, sertraline, Elavil®, Luvox®, Pamelor®, Paxil®, Prozac®, or Zoloft®). Check along with your physician immediately you probably have anxiousness, restlessness, quick heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or listening to issues that aren’t there.

When selegiline is taken at doses of 10 mg or much less per day for the therapy of Parkinson’s illness, there are not any restrictions on meals or drinks you eat or drink. However, the prospect exists that harmful reactions, together with sudden hypertension, might happen if doses increased than these used for Parkinson’s illness are taken with sure meals, drinks, or different medicines. These meals, drinks, and medicines embody:

  • Foods which have a excessive tyramine content material (commonest in meals which can be aged or fermented to extend their taste), akin to cheeses, fava or broad bean pods, yeast or meat extracts, smoked or pickled meat, poultry, or fish, fermented sausage (bologna, pepperoni, salami, summer season sausage) or different fermented meat, sauerkraut, or any overripe fruit. If a listing of those meals and drinks is just not given to you, ask your physician to offer one.
  • Alcoholic drinks or alcohol-free or reduced-alcohol beer and wine.
  • Large quantities of caffeine-containing meals or drinks akin to espresso, tea, cola, or chocolate.
  • Any different medication except authorised or prescribed by your physician. This particularly consists of nonprescription (over-the-counter [OTC]) medication, akin to that for colds (together with nostril drops or sprays), cough, bronchial asthma, hay fever, and urge for food management, “keep awake” merchandise, or merchandise that make you sleepy.

How to Store Selegiline

  • Store the drugs in a closed container at room temperature, away from warmth, moisture, and direct gentle. Keep from freezing.
  • Keep out of the attain of youngsters.
  • Do not hold outdated medication or medication now not wanted.
  • Ask your healthcare skilled how you must eliminate any medication you don’t use.

Selegiline Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur:

  • Twitching
  • twisting
  • uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

Other negative effects not listed can also happen in some sufferers. If you discover some other results, verify along with your healthcare skilled. Call your physician for medical recommendation about negative effects.

Symptoms of Overdose

  • Agitation
  • chest pain
  • difficulty opening the mouth or lockjaw
  • dizziness (severe) or fainting
  • fast or irregular pulse (continuing)
  • high fever
  • high or low blood pressure
  • severe spasm where the head and heels are bent backward and the body arched forward
  • trouble breathing


Information concerning psychotic disorders, included within the review of Selegiline, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor. The internet drug store does not think any type of lawful obligation or responsibility for injury, occurring from any type of use information on irregular antipsychotic representative Selegiline.


⚠Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.

Frequently asked questions

  • What is Selegiline?

    Selegiline is a monoamine oxidase inhibitor, which used to treat the symptoms of Parkinson's disease. This is a case of the brain that affects motion. 

  • What to do if you miss a dose?

    If you miss a dose of Selegiline, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  • What if u take too much Selegiline?

    If an overdose happens name your physician or 911. You might have pressing medical care. You might also contact the poison management at your local hospital

  • How to store Selegiline?

    Store at room temperature between 20-25 C (68-77 F).

  • What Should I Avoid While Taking Selegiline?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Selegiline. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  • What are the side effects of Selegiline?

    They may include all types of an allergic reaction. Also, the most possible side effects include confusion, sudden and severe headache, blurred vision, nausea, problems with speech or balance, vomiting, seizure, chest pain and sudden numbness or weakness; feeling light-headed, fainting; hallucinations; feeling restless, agitated, or irritable; twitching muscle movements; painful or difficult urination. 

  • What are the contraindication?

    Selegiline is not allowed to people who are hypersensitive to selegiline or other components of the formulation. Do not take Demerol or such types of narcotic while you are taking Selegiline. Also do not use Selegiline if you have used any of the following drugs within the past 14 days: meperidine, propoxyphene, or tramadol; methadone; cough or cold medicine that contains dextromethorphan; or other MAO inhibitors such as isocarboxazid, tranylcypromine, phenelzine, rasagiline, or transdermal selegiline.

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Last Updated on October 15, 2021 by Toni El Clikos

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