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What is Isotretinoin?

Accutane is a brand-name model of the drug isotretinoin. The model is not obtainable within the United States. However, the generic model of isotretinoin and different brand-name variations, comparable to Absorica, are nonetheless obtainable.

Isotretinoin is used to deal with a sort of extreme zits known as nodular zits. Nodular zits causes crimson, swollen, tender lumps to kind within the pores and skin. If untreated, nodular zits can result in everlasting scarring.

Your physician will solely prescribe isotretinoin when different remedies, together with antibiotics, haven’t helped your nodular zits. While isotretinoin may also help deal with nodular zits, it may additionally trigger many uncomfortable side effects. Some of those results will be critical, particularly if the drug is taken throughout being pregnant.

How to make use of Isotretinoin?

Read the Medication Guide offered by your pharmacist earlier than you begin utilizing isotretinoin and every time you get a refill. Read and signal a Patient Information/Informed Consent kind earlier than you begin taking this treatment. If you’ve got any questions on isotretinoin, seek the advice of your physician or pharmacist earlier than taking the treatment.

Swallow capsules complete. Do not crush or chew them. Isotretinoin is normally taken twice day by day for 15-20 weeks, or as directed by your physician. Directions for many generic types of isotretinoin state that it needs to be taken with meals. However, the FDA has indicated that the Absorica model could also be taken with or with out meals. Food helps improve absorption of this drug into your bloodstream. Ask your physician or pharmacist for extra data. Take this drug with a full glass of water, and don’t lie down for at the least 10 minutes after taking it.

The dosage is predicated in your medical situation, weight, and response to remedy.

Your zits could worsen in the course of the first few days of taking this drug, and it could take as much as 1-2 months earlier than you discover the total good thing about this treatment. If extreme zits returns, a second course of remedy could also be began after you’ve got stopped taking the drug for two months. The producer doesn’t advocate long-term use of isotretinoin. Do not take greater than the advisable dose.

Since this drug will be absorbed by the pores and skin and lungs and will hurt an unborn child, ladies who’re pregnant or who could develop into pregnant shouldn’t deal with this treatment or breathe the mud from the capsules.

Side Effects

The delicate uncomfortable side effects of isotretinoin can embrace:

  • dry pores and skin
  • chapped lips
  • dry eyes
  • dry nostril that will result in nosebleeds

These uncomfortable side effects could go away on their very own. If they don’t go away or in the event that they develop into an issue, name your physician. The extra critical uncomfortable side effects of isotretinoin can have long-term or everlasting results. However, aside from elevated ldl cholesterol and joint and muscle issues, these uncomfortable side effects are all fairly uncommon.

Increased ldl cholesterol

Isotretinoin can improve the degrees of fat and ldl cholesterol in your blood. During your remedy, your physician could recommend common blood exams to verify your fats and levels of cholesterol. You’re at increased danger of those issues when you:

  • have diabetes
  • are overweight
  • have metabolic syndrome
  • drink alcohol

This facet impact, in case you have it, sometimes goes away whenever you end your remedy with isotretinoin.

Joint and muscle issues

Tell your physician when you plan to do laborious bodily exercise throughout remedy with isotretinoin. Isotretinoin may cause ache in your bones, joints, muscle tissue, and ligaments. It may also stunt the expansion of lengthy bones in teenagers, which may have everlasting results. If you’ve got any of the next signs, name your physician instantly:

  • new again ache
  • new joint ache
  • damaged bone

If you break a bone, you should definitely inform all the healthcare suppliers that take care of you that you simply take isotretinoin.

If you’ve got muscle weak spot, with or with out ache, cease taking isotretinoin and name your physician instantly. Muscle weak spot is usually a signal of significant muscle injury and could possibly be a everlasting impact.

Pressure in your mind

Rarely, isotretinoin may cause elevated stress on the mind. This can result in everlasting lack of eyesight and, in uncommon circumstances, demise. Stop taking isotretinoin and name your physician instantly in case you have any of those signs:

  • extreme headache
  • blurry imaginative and prescient
  • dizziness
  • nausea and vomiting

If you’ve got both of those signs, name 911 instantly:

  • seizures
  • stroke

Skin rash

Although uncommon, a rash attributable to isotretinoin will be critical. Stop utilizing isotretinoin and name your physician instantly in case you have any of the next signs:

  • conjunctivitis (pink eye)
  • a rash with fever
  • blisters in your arms, legs, or face
  • peeling pores and skin
  • sores in your mouth, throat, nostril, or eyes (on the lid or the attention itself)

Organ injury

Isotretinoin can injury your inner organs. These organs embrace your liver, pancreas, intestines, and esophagus (the tube connecting your mouth and abdomen). The injury could not get higher even after you cease taking isotretinoin.

This facet impact is uncommon. Still, cease taking isotretinoin and name your physician instantly in case you have any of the next signs:

  • extreme ache in your abdomen, chest, or decrease stomach
  • hassle swallowing or ache throughout swallowing
  • new or worsening heartburn
  • diarrhea
  • bleeding out of your rectum
  • yellowing of your pores and skin or the whites of your eyes
  • darkish urine

Hearing issues

Isotretinoin may cause critical listening to issues in uncommon circumstances. Stop utilizing isotretinoin and name your physician instantly in case your listening to will get worse or in case you have ringing in your ears. Any listening to loss could also be everlasting.

Vision and eye issues

Isotretinoin may cause imaginative and prescient issues comparable to blurry imaginative and prescient, double imaginative and prescient, and tunnel imaginative and prescient. This drug may also scale back your skill to see in the dead of night. Vision issues could repair themselves after you cease taking the drug or the injury could also be everlasting.

Isotretinoin may cause your eyes to provide extra tears than regular. If you put on contact lenses, you might have hassle sporting them whereas taking isotretinoin. Like the opposite imaginative and prescient issues, this downside could go away after your cease remedy or it could be everlasting.

All of those imaginative and prescient and eye issues are uncommon. Nevertheless, cease taking isotretinoin and name your physician instantly in case you have issues together with your imaginative and prescient, an elevated quantity of tears, or painful or fixed eye dryness.

Allergic reactions

Isotretinoin may cause critical allergic reactions in uncommon circumstances. Stop taking isotretinoin and name your physician in case you have a rash, crimson patches, or bruises in your legs or a fever. If you’ve got any of the next signs, cease taking isotretinoin and name 911 or go to the closest emergency room:

  • hives
  • swelling in your face or mouth
  • hassle respiratory

Diabetes and different blood sugar issues

Isotretinoin could trigger blood sugar issues, together with diabetes. Call your physician in case you have any of the next signs:

  • extreme thirst
  • urinating extra typically
  • blurry imaginative and prescient
  • elevated tiredness

These could also be diabetic signs attributable to the drug. This impact is uncommon, although.

Low crimson blood cell ranges

Another uncommon, critical facet impact is a lower in blood cell ranges. Low ranges of crimson blood cells may cause issues comparable to anemia. Call your physician in case you have any of the next signs:

  • excessive tiredness
  • weak spot
  • dizziness
  • coldness in your fingers and ft
  • pale pores and skin

Low white blood cell ranges

Low ranges of white blood cells increase your danger of infections. Call your physician in case you have any of the next signs:

  • fever
  • frequent infections

This facet impact is uncommon.

Mental well being points

Rarely, isotretinoin may cause critical psychological well being issues. These embrace despair, psychosis (shedding contact with actuality), and suicidal ideas or actions. Stop utilizing isotretinoin and name your physician instantly in case you have any of the next signs:

  • elevated emotions of unhappiness
  • crying spells
  • lack of curiosity in actions you get pleasure from
  • sleeping an excessive amount of or hassle sleeping
  • performing extra irritable, offended, or aggressive than common
  • modifications in urge for food or weight
  • lack of power
  • withdrawal from buddies or household
  • hassle concentrating
  • emotions of worthlessness or guilt
  • ideas of wounding your self or taking your individual life
  • hallucinations (seeing or listening to issues that aren’t actual)


Before taking isotretinoin, inform your physician or pharmacist in case you are allergic to it; or to vitamin A-related medication (different retinoids comparable to tretinoin); or in case you have every other allergic reactions. This product could comprise inactive elements (comparable to soybean, parabens), which might trigger allergic reactions or different issues. Some people who find themselves allergic to peanuts can also be allergic to soy. Talk to your pharmacist for extra particulars.
Before utilizing this treatment, inform your physician or pharmacist your medical historical past, particularly of: diabetes, household or private historical past of excessive blood fat (triglycerides), psychological/temper issues (comparable to despair), liver illness, weight problems, consuming problems (e.g., anorexia nervosa), alcohol abuse, pancreatitis, bone loss situations (e.g., osteoporosis/osteomalacia, decreased bone density).
Do not donate blood when you are taking isotretinoin and for at the least 1 month after you cease taking it.
This treatment could make you extra delicate to the solar. Limit your time within the solar. Avoid tanning cubicles and sunlamps. Use sunscreen and put on protecting clothes when outdoor. Tell your physician instantly when you get sunburned or have pores and skin blisters/redness.
Isotretinoin can have an effect on your night time imaginative and prescient. Do not drive, use equipment, or do any exercise that requires clear imaginative and prescient after darkish till you might be positive you possibly can carry out such actions safely.


Drug interactions could change how your medicines work or improve your danger for critical uncomfortable side effects. This doc doesn’t comprise all potential drug interactions. Keep a listing of all of the merchandise you utilize (together with prescription/nonprescription medication and natural merchandise) and share it together with your physician and pharmacist. Do not begin, cease, or change the dosage of any medicines with out your physician’s approval.

Some merchandise that will work together with this drug are: tetracyclines (comparable to minocycline, tetracycline), vitamin A-type medication (comparable to acitretin, bexarotene), vitamin A, medication that trigger bone loss (for instance, anti-seizure medication comparable to phenytoin, corticosteroids comparable to prednisone).

Tell your physician whenever you begin any new drug and talk about when you ought to use extra dependable contraception. Also inform your physician in case you have any new recognizing or breakthrough bleeding, as a result of these could also be indicators that your contraception is just not working nicely.

Missed Dose

If you miss a dose, skip the missed dose. Take your subsequent dose on the common time. Do not double the dose to catch up.


If somebody has overdosed and has critical signs comparable to passing out or hassle respiratory, name 911. Otherwise, name a poison management heart instantly. US residents can name their native poison management heart at 1-800-222-1222. Canada residents can name a provincial poison management heart. Symptoms of overdose could embrace: vomiting, abdomen ache, facial flushing, headache, lack of stability.


Store at room temperature away from gentle and moisture. Do not retailer within the lavatory. Keep all medicines out of attain of kids and pets.

Disclaimer of legal responsibility

Pfizer is just not affiliated with this web site. The model identify and logos and pictures used are the property of Pfizer. The content material of this web site is for informational functions solely. We don’t provide, market or ship medicines ourselves and refer you to respected internet shops on the Internet. Always seek the advice of a doctor when utilizing medicines.

On this web site we don’t promote any medicines and refer guests to trusted Internet suppliers. In this fashion, we prevent and the perfect value to individuals many issues and you’ll simply and legally get hold of this highly effective drugs.

Frequently requested questions

  • How does isotretinoin work?

    Isotretinoin belongs to a class of drugs called retinoids. The exact way the drug works is not known, but it’s thought to decrease the amount of oil made by certain glands in your skin. Less oil on your skin gives the acne-causing bacteria less to feed on. It’s also thought that isotretinoin helps prevent dead skin cells from clogging pores. With fewer clogged pores, bacteria have fewer places to grow.

  • What if u take too much Isotretinoin?

    If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.

  • What to do if you miss a dose?

    Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

  • How to store Isotretinoin?

    Store at room temperature between 59-86 degrees F (between 15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines out of reach of children and pets.

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Last Updated on August 22, 2021 by Toni El Clikos

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