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Active Ingredient: Fluoxetine
Brand Name: Prozac

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What is Fluoxetine or Prozac?

Fluoxetine is an antidepressant. The best-known brand with this active ingredient is Prozac. Fluoxetine improves your mood and reduces fears and anxiety symptoms (such as fretting, trouble sleeping, irritability and trembling).

  • For depression, anxiety disorders (such as obsessive-compulsive disorder, panic disorder, social phobia and post-traumatic stress disorder) and the eating disorder bulimia nervosa. Also for symptoms associated with premenstrual syndrome.
  • Fluoxetine belongs to the serotonin reuptake inhibitors, or SSRIs.
  • It regulates the amount of serotonin in the brain. This body’s own substance plays a role in emotions and moods. SSRIs improve mood and reduce anxiety.

How Fluoxetine Works

SSRIs like fluoxetine work by preventing serotonin from being reabsorbed rapidly after it is released. When serotonin is absorbed too fast, it is not able to help neurons communicate as well; with fewer signals moving between neurons, mood and physical energy can below. However, an SSRI allows serotonin to remain in the synapses – the spaces between neurons – for longer, helping neurons communicate with each other. This elevates mood and improves energy.

What is the main purpose of Prozac?

Fluoxetine is a type of antidepressant known as an SSRI (selective serotonin reuptake inhibitor). It is often used to treat depression, and also sometimes obsessive compulsive disorder and bulimia. Fluoxetine helps many people recover from depression, and it has fewer unwanted effects than older antidepressants

What does Fluoxetine do to a normal person?

Overview. As an SSRI, Prozac works by preventing the brain from reabsorbing naturally occurring serotonin. Serotonin is involved in mood regulation. In this way, Prozac helps the brain to maintain enough serotonin so that you have a feeling of well-being, resulting from improved communication between brain cells.

What happens when you first start taking Prozac?

You can feel drowsy in the first few days of taking fluoxetine. However, it should get better after the first week or two. You may become more anxious, or it may make you irritable. This should settle after a couple of weeks.

Can Fluoxetine work the first day?

While many patients hope to experience relief from their symptoms immediately, Prozac is a long term antidepressant that needs time to work. Fluoxetine often begins to improve physical symptoms of depression like irregular sleep, appetite, or energy levels, first, sometimes in as little as one to two weeks.

Is Prozac a narcotic?

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) medication. SSRIs are not controlled substances and most people who are prescribed these medications do not abuse them.

What is better Fluoxetine or Zoloft?

In a double-blind, clinical trial, both Zoloft and Prozac improved depression based on different scores for depression and anxiety as well as sleep. While both SSRIs were found to be effective, Zoloft was found to have lower severity of side effects

What type of symptoms can Prozac treat?

Doctors prescribe Prozac for depression and for anxiety disorders, such as obsessive-compulsive disorder, panic disorder, social phobia and post-traumatic stress disorder. It is also used for bulimia nervosa, for certain menstrual complaints (namely premenstrual syndrome), and for nerve pain (pain caused by damage to a nerve).


In depression, you are gloomy, irritable and have less interest in activities. You have trouble having fun and lose energy. Feelings of despair and worthlessness are also characteristic of depression. Fluoxetine helps reduce depressive symptoms, giving you more energy and making you feel better about yourself.

Anxiety and panic disorder

Anxiety is normal, but it shouldn’t affect your daily life. Anxiety and panic make you fret. Sometimes it is so bad that the anxiety or panic attacks are accompanied by physical symptoms, such as sweating, trembling, dizziness and nausea. Fluoxetine can help you reduce anxiety and fretting. It makes the attacks less intense.

Social phobia

With social phobia you are afraid of certain situations in the social context, such as presentations or meetings. You are afraid of “going off. Sometimes the fear is so bad that it makes you shake and sweat. In addition to behavioral therapy, the doctor may also advise you to take fluoxetine.

Post-traumatic stress disorder (PTSD)

With PTSD, complaints arise because you have experienced a shocking, traumatic event. This causes you to have gloomy, depressive moods and you are irritable. Insomnia and nightmares can also occur. A doctor can prescribe fluoxetine to reduce depressive feelings with PTSD.

Bulimia nervosa

Bulimia nervosa is a chronic, psychological eating disorder. Some periods you eat an enormous amount of food in a short period of time, after which you try to get rid of the food again by, for example, exercising heavily or vomiting. An eating disorder is often accompanied by guilt, depression and disgust with yourself. The doctor may prescribe fluoxetine to reduce depressive symptoms and anxiety. In other eating disorders, such as anorexia nervosa, studies often show no effect of fluoxetine.


Prozac are is in tablet, capsule, and liquid form. Sizes of fluoxetine doses include 10 mg, 20 mg, and 40 mg; Sarafem specifically is found in 10 mg, 15 mg, and 20 mg forms. Dosing depends largely on which condition fluoxetine has been prescribed to treat. For example, Sarafem may be taken once per day consistently, or it could be taken for specific days in the woman’s menstrual cycle. Prozac Weekly, which comes in 90 mg, is only taken once per week, but lower-dose versions of fluoxetine are taken once per day. Fluoxetine is always taken orally.

Like other SSRIs, fluoxetine needs a few weeks to fully work on brain chemistry

The medication should be taken consistently for 4-6 weeks before it is in full effect. When fluoxetine works well, the medication elevates, then stabilizes mood. Mood swings and irritability can still occur, but they are less likely to occur, as are other depression-related symptoms like feeling guilty without cause, feeling sad, sleeping too much, and feeling hopeless.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
If you miss a dose of Prozac Weekly, take the missed dose as soon as you remember and take the next dose 7 days later. However, if it is almost time for the next regularly scheduled weekly dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

What is the best time of day to take Prozac?

For example, the manufacturer of Prozac (fluoxetine) recommends it be taken in the morning because it can make some people feel more energized, especially at the beginning of treatment.

Side Effects

Like other psychiatric medications, SSRIs like fluoxetine can cause side effects. These are rare in most people who take the medication, although experiencing side effects could be an indication that the dose is too high and should be adjusted by the person’s physician or therapist. Side effects include:

  • Nervousness
  • Diarrhea
  • Sore throat
  • Dry mouth
  • Physical weakness
  • Fatigue
  • Trembling or shaking that is involuntary
  • Changes to appetite or weight
  • Changes to sex drive
  • Increased sweating

Weight gain is a common side effect from taking fluoxetine

While this is typically not a dangerous side effect for many people, it can reduce self-image and sense of self-worth. For some people, weight-related diseases like diabetes or heart disease can occur, so it is important to work with a medical professional to moderate weight gain if it occurs. More serious side effects, like an allergic reaction, can indicate a serious, negative interaction with the medication. Call 911 for emergency medical treatment if these side effects occur:

    • Rash
    • Hives
    • High fever
    • Joint pain
    • Swelling to the face, lips, throat, tongue, eyes, hands, feet, or lower legs
    • Trouble breathing or swallowing Confusion
    • Rapid or irregular heartbeat
    • High blood pressure
    • Extreme muscle stiffness
    • Aggression or violence
    • Hallucinations
    • Seizures

People under the age of 24 years old are also more likely to experience suicidal thoughts or actions while taking fluoxetine.

Long term side effects from using Fluoxetine

There are no severe long-term effects for adults who take fluoxetine, and there are few studies on the side effects on children who take fluoxetine. Taking fluoxetine or other SSRIs while pregnant has a less than 1 per cent chance of causing birth defects to the fetus, so a woman who is pregnant or who plans to become pregnant should speak to her doctor about taking this medication.

Fluoxetine may also exacerbate some pre-existing health conditions, particularly heart problems. However, the medication has not been linked to triggering these problems. This medication is known to lead to physical dependence; although this is not the same as addiction, the condition can cause withdrawal symptoms.

Is Fluoxetine Addictive?

Fluoxetine and other SSRIs are not considered to be addictive, in part because they do not act quickly on brain chemistry to induce euphoria, or high. They take weeks to fully settle into the system; in fact, Prozac is sometimes prescribed to treat alcohol use disorder after detox. The medication reduces cravings, and stabilizes mood, so the person is less likely to drink to self-medicate a mood disorder. While some people may attempt to abuse fluoxetine, these individuals typically have a history of substance abuse problems, or polydrug abuse issues, and are at greater risk of struggling with any prescription medication.

Drug interactions

Fluoxetine can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Using fluoxetine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with fluoxetine may cause you to bruise or bleed easily.

Tell your doctor about all your current medicines. Many drugs can affect fluoxetine, especially:

  • any other antidepressant;
  • St. John’s Wort;
  • tryptophan (sometimes called L-tryptophan);
  • a blood thinner – warfarin, Coumadin, Jantoven;
  • medicine to treat anxiety, mood disorders, thought disorders, or mental illness – amitriptyline, buspirone, desipramine, lithium, nortriptyline, and many others;
  • medicine to treat ADHD or narcolepsy – Adderall, Concerta, Ritalin, Vyvanse, Zenzedi, and others;
  • migraine headache medicine – rizatriptan, sumatriptan, zolmitriptan, and others; or
  • narcotic pain medicine – fentanyl, tramadol.

This list is not complete and many other drugs may affect fluoxetine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.


Store Prozac at room temperature between 59°F and 86°F (15°C to 30°C). Keep PROZAC away from light.

⚠Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.

Frequently asked questions

  1. What is Prozac?

    Fluoxetine belongs to the serotonin reuptake inhibitors, or SSRIs. It regulates the amount of serotonin in the brain. This body's own substance plays a role in emotions and moods. SSRIs improve mood and reduce anxiety. Doctors prescribe it for depression and for anxiety disorders, such as obsessive-compulsive disorder, panic disorder, social phobia and post-traumatic stress disorder. It is also used for bulimia nervosa, for certain menstrual complaints (namely premenstrual syndrome), and for nerve pain (pain caused by damage to a nerve). Look at all the different types of Fluoxetine here.

  2. What should i do when i forget a dose?

    It is important that you continue to take this medicine consistently. If you do forget a dose, take it within 16 hours. If it is less than 8 hours before you are due to take the next dose, skip the forgotten dose. Do not take a double dose.

  3. How long can I use this drug without risks?

    No, you may not stop fluoxetine overnight. Will you stop at once? Then you may experience symptoms. For example, anxiety, dizziness, vertigo, headaches, nausea and sweating. These symptoms are also called withdrawal symptoms. This is because your body is used to this medicine. Not everyone suffers from withdrawal symptoms to the same extent.

    Do you want to stop taking fluoxetine? Then talk to your doctor or pharmacist. Together you will agree on the best way to stop. You will often stop taking fluoxetine within 2 weeks. See how you react and tell your doctor or pharmacist. They can help you if you develop symptoms. Look at all the different types of Fluoxetine here.

  4. Why should you taper off fluoxetine?

    Fluoxetine tapering is important when using fluoxetine for a longer period of time. Stopping fluoxetine often leads to withdrawal symptoms. Therefore, do not simply stop taking the drug unless allergic reactions occur, such as itching, swollen face or shortness of breath. Also, always consult with your doctor if you want to stop taking the drug. You should phase out fluoxetine carefully so that your body can get used to it.

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Last Updated on November 19, 2021 by Toni El Clikos

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