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Active Ingredient: Plavix
Brand(s): Plavix

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What is Clopidogrel

Clopidogrel is an irregular antipsychotic medicine. Blocks dopamine receptors of CNS as well as conflicts dopamine button in basic gangliya as well as in limbic a component of neoncephalon. It is taken at hypersensitivity, disorders of hemopoietic system (along with in anamnesis), alcoholic as well as harmful psychosis, myasthenia, comas.

Plavix Drug Uses

Clopidogrel is used alone or along with aspirin to reduce the possibility of a coronary heart assault or stroke. It is given to sufferers with acute coronary syndrome (ACS), to sufferers who’ve already had a coronary heart assault, extreme chest ache, or a stroke, or to sufferers with different circulation issues (eg, peripheral arterial illness) that would trigger a stroke or coronary heart assault. Acute coronary syndrome is a situation the place the blood stream to the center is blocked.

A coronary heart assault or stroke might happen when a blood vessel is blocked by a blood clot. Clopidogrel is a platelet inhibitor. It reduces the possibility {that a} dangerous blood clot will kind by stopping platelets from clumping collectively within the blood. Clopidogrel may enhance the possibility of great bleeding in some individuals.

What Should You Discuss To Your Doctor Before Using This Medicine

  1. General Risk Of Bleeding: P2Y12 inhibitors (Thienopyridines), including Clopidogrel, increase the risk of bleeding. P2Y12 inhibitors (Thienopyridines), inhibit platelet aggregation for the lifetime of the platelet (7-10 days). Because the half-life of clopidogrel active metabolite is short, it may be possible to restore hemostasis by administering exogenous platelets; however, blood transfusions within 4 hours of the loading dose or 2 hours of the maintenance dose may be less effective.

  2. Discontinuation Of Clopidogrel: Discontinuation of Plavix increases the risk of cardiovascular events. If Clopidogrel must be temporarily discontinued (e.g., to treat bleeding or for surgery with a major risk of bleeding), restart it as soon as possible. When possible, interrupt therapy with Plavix for five days prior to such surgery. Resume Clopidogrel as soon as hemostasis is achieved.

  3. Thrombotic Thrombocytopenic Purpura (TTP): TTP, sometimes fatal, has been reported following use of Clopidogrel, sometimes after a short exposure. TTP is a serious condition that requires urgent treatment including plasmapheresis (plasma exchange). It is characterized by thrombocytopenia, microangiopathic hemolytic anemia (schistocytes [fragmented RBCs] seen on peripheral smear), neurological findings, renal dysfunction, and fever.

  4. Cross-Reactivity Among Thienopyridines: Hypersensitivity including rash, angioedema or hematologic reaction has been reported in patients receiving Clopidogrel, including patients with a history of hypersensitivity or hematologic reaction to other thienopyridines.

Clopidogrel Drug Interactions

Although sure medicines shouldn’t be used collectively in any respect, in different instances two totally different medicines could also be used collectively even when an interplay may happen. In these instances, your physician might need to change the dose, or different precautions could also be mandatory. When you take this medication, it’s particularly vital that your healthcare skilled know if you’re taking any of the medicines listed under. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Using this medication with any of the next medicines shouldn’t be really helpful. Your physician might determine to not deal with you with this medicine or change a number of the different medicines you are taking.

  • Defibrotide

Using this medication with any of the next medicines is normally not really helpful, however could also be required in some instances. If each medicines are prescribed collectively, your physician might change the dose or how typically you utilize one or each of the medicines.

  • Aceclofenac
  • Acemetacin
  • Alfentanil
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amiodarone
  • Amlodipine
  • Amtolmetin Guacil
  • Anagrelide
  • Anileridine
  • Apalutamide
  • Apixaban
  • Ardeparin
  • Argatroban
  • Aspirin
  • Bemiparin

Other Interactions

Certain medicines shouldn’t be used at or across the time of consuming meals or consuming sure kinds of meals since interactions might happen. Using alcohol or tobacco with sure medicines may trigger conditions to happen. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Using this medication with any of the next is normally not really helpful, however could also be unavoidable in some instances. If used collectively, your physician might change the dose or how typically you utilize this medication, or offer you particular directions about using meals, alcohol, or tobacco.

  • Grapefruit Juice

Other Medical Problems Plavix

The presence of different medical issues might have an effect on using this medication. Make certain you inform your physician if in case you have every other medical issues, particularly:

  • Bleeding
  • Intracranial hemorrhage
  • Stroke
  • Transient ischemic assault

Proper Usage of Clopidogrel

Take this medication precisely as directed by your physician. Clopidogrel is not going to work correctly if you happen to take much less of it than directed. Taking extra clopidogrel than directed might enhance the possibility of great uncomfortable side effects with out growing the useful results.

  • This medication comes with a Medication Guide. It is essential that you simply learn and perceive this info. Be certain to ask your physician about something you don’t perceive.
  • You might take this medication with or with out meals.
  • If you might be additionally taking omeprazole (Prilosec®) or esomeprazole (Nexium®), don’t use it on the similar time that you simply take this medication. Talk along with your physician about utilizing a special antacid.
  • Your physician might let you know to take aspirin if you are utilizing clopidogrel. Do not change the dose or cease taking the aspirin with out speaking to your physician first.

Clopidogrel Dosage

The dose of this medication can be totally different for various sufferers. Follow your physician’s orders or the instructions on the label. The following info consists of solely the common doses of this medication. If your dose is totally different, don’t change it until your physician tells you to take action.

The quantity of medication that you simply take will depend on the energy of the medication. Also, the variety of doses you are taking every day, the time allowed between doses, and the size of time you are taking the medication rely on the medical drawback for which you might be utilizing the medication.

  • For oral dosage kind (tablets):
    • For prevention of coronary heart assault or stroke in sufferers with acute coronary syndrome (ACS):
      • Adults: At first, 300 milligrams (mg) taken as a single dose. Then, a upkeep dose of 75 mg as soon as a day. Your physician may offer you aspirin along with this medication.
      • Children: Use and dose should be decided by your physician.
    • For prevention of coronary heart assault or stroke in sufferers with a historical past coronary heart assault, stroke, or peripheral arterial illness:
      • Adults: 75 milligrams (mg) as soon as a day.
      • Children: Use and dose should be decided by your physician.

Missed Dosage

If you miss a dose of this medication, take it as quickly as attainable. However, whether it is nearly time in your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

Plavix Storage

  1. Store the medication in a closed container at room temperature, away from warmth, moisture, and direct gentle. Keep from freezing.
  2. Keep out of the attain of youngsters.
  3. Do not preserve outdated medication or medication now not wanted.
  4. Ask your healthcare skilled how you need to eliminate any medication you don’t use.

Clopidogrel Precautions

It is essential that your physician examine your progress at common visits. This will enable your physician to see if the medication is working correctly and to determine if you happen to ought to proceed to take it. Blood assessments could also be wanted to examine for side effects.

Your physician might do a genetic take a look at earlier than prescribing this medication to find out if in case you have a deficiency in a liver enzyme known as CYP2C19. This medication might not work as nicely if in case you have this situation.

Tell all medical medical doctors, dentists, nurses, and pharmacists you go to that you’re taking this medication. Clopidogrel might enhance the chance of great bleeding throughout a surgical procedure, different medical procedures (eg, coronary stent process), or some sorts of dental work. You might have to cease utilizing this medication at the very least 5 days earlier than a surgical procedure, medical process, or dental work. Do not cease taking your medication with out your physician’s permission.

While you might be utilizing this medication, if in case you have any form of bleeding, it could take longer than ordinary to cease, particularly if you happen to harm your self. Stay away from tough sports activities or different conditions the place you might be bruised, minimize, or injured. Be cautious when utilizing sharp objects, together with razors and fingernail clippers.

This medication might enhance your probability of bleeding or bruising. Check along with your physician instantly if you happen to discover any uncommon bleeding or bruising, black, tarry stools, blood within the urine or stools, or pinpoint pink spots in your pores and skin. Avoid choosing your nostril. If you could blow your nostril, blow it gently.

Clopidogrel Side Effects

Along with its wanted results, a medication might trigger some negative effects. Although not all of those uncomfortable side effects might happen, in the event that they do happen they might want medical consideration.

Check along with your physician instantly if any of the next uncomfortable side effects happen:

  • Collection of blood underneath the pores and skin
  • deep, darkish purple bruise
  • itching, ache, redness, or swelling
  • Bloody nostril
  • bloody, black, or tarry stools
  • vomiting of blood or materials that appears like espresso grounds

Other negative effects not listed can also happen in some sufferers. If you discover some other results, verify along with your healthcare skilled. Call your physician for medical recommendation about negative effects.


Information concerning psychotic disorders, included within the review of Clopidogrel, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.


⚠Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.

Frequently asked questions

  • What is Clopidogrel Plavix?

    Plavix is used to diminish the risk of heart attacks and strokes caused by blood clots is increased in patients with a recent history of stroke, heart attack and peripheral vascular disease. It is used to prevent ischemic disorders like myocardial infarction, stroke, thrombosis of peripheral arteries and others.

  • What to do if you miss a dose?

    If you miss a dose of Clopidogrel, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  • What if u take too much Plavix?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  • How to store Clopidogrel?

    Store Plavix tablets and capsules should be stored at room temperature between 15-30 C (59-86 F).

  • What Should I Avoid While Taking Clopidogrel?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Plavix. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  • What are the side effects of Clopidogrel Plavix?

    Most frequent side effects include bleeding in stomach or guts, hemorrhagic stroke, neutropenia, thrombocytopenia, abdominal pain, dyspepsia, gastritis, constipation, ulcers in the gastrointestinal tract, diarrhoea, allergy.

  • What are the Contraindication?

    Hypersensitivity, severe liver failure, acute bleeding, ulcer of stomach or duodenum, ulcerous colitis, tuberculosis and other diseases predisposing to bleeding, pregnancy, breastfeeding, neonatal period.

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Last Updated on October 19, 2021 by Toni El Clikos

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