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What is Amantadine?

Symmetrel Drug Uses

Symmetrel is an antidyskinetic medication. It is used to deal with Parkinson’s illness (generally known as “paralysis agitans” or “shaking palsy”) and its signs, together with dyskinesia (sudden uncontrolled actions). It could also be given alone or together with different medicines (eg, levodopa) for Parkinson’s illness. By enhancing muscle management and decreasing stiffness, this medication permits extra regular actions of the physique because the illness signs are decreased. Amantadine can also be used to deal with stiffness and shakiness attributable to sure medicines which might be used to deal with nervous, psychological, and emotional situations.

Amantadine can also be an antiviral medication. It is used to stop or deal with sure influenza (flu) infections (sort A). It could also be given alone or along with flu photographs. Amantadine is not going to work for colds, different kinds of flu, or different virus infections.

What You Should Know Before Using This Medicine

1. Renal disease: Because Amantadine is mainly excreted in the urine, it accumulates in the plasma and in the body when renal function declines. Thus, the dose of Amantadine should be reduced in patients with renal impairment and in individuals who are 65 years of age or older.
2. Liver disease: Care should be exercised when administering Amantadine to patients with liver disease. Rare instances of reversible elevation of liver enzymes have been reported in patients receiving Amantadine , though a specific relationship between the drug and such changes has not been established.
3. Melanoma: Epidemiological studies have shown that patients with Parkinson’s disease have a higher risk (2-to approximately 6-fold higher) of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson’s disease or other factors, such as drugs used to treat Parkinson’s disease, is unclear.
4. For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using Amantadine for any indication. Ideally, periodic skin examinations should be performed by appropriately qualified individuals (e.g., dermatologists).
5. Nursing Mothers: Amantadine is excreted in human milk. Use is not recommended in nursing mothers.
6. Pediatric Use: The safety and efficacy of Amantadine in newborn infants and infants below the age of 1 year have not been established.
7. Usage in the Elderly: Because Amantadine is primarily excreted in the urine, it accumulates in the plasma and in the body when renal function declines. Thus, the dose of Amantadine should be reduced in patients with renal impairment and in individuals who are 65 years of age or older. The dose of Amantadine may need reduction in patients with congestive heart failure, peripheral edema, or orthostatic hypotension.

Amantadine Drug Interactions

Although sure medicines shouldn’t be used collectively in any respect, in different instances two totally different medicines could also be used collectively even when an interplay may happen. In these instances, your physician might need to change the dose, or different precautions could also be mandatory. When you take this medication, it’s particularly vital that your healthcare skilled know if you’re taking any of the medicines listed under. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Using this medication with any of the next medicines shouldn’t be really helpful. Your physician might determine to not deal with you with this medicine or change a number of the different medicines you are taking.

• Potassium Chloride

Using this medication with any of the next medicines is normally not really helpful, however could also be required in some instances. If each medicines are prescribed collectively, your physician might change the dose or how typically you utilize one or each of the medicines.

• Amifampridine
• Bupropion
• Donepezil
• Glucagon
• Memantine
• Methacholine
• Metoclopramide
• Quetiapine
• Secretin Human

Other Interactions

Certain medicines shouldn’t be used at or across the time of consuming meals or consuming sure kinds of meals since interactions might happen. Using alcohol or tobacco with sure medicines may trigger conditions to happen. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Other Medical Problems Symmetrel

The presence of different medical issues might have an effect on using this medication. Make certain you inform your physician if in case you have every other medical issues, particularly:

• Congestive coronary heart failure
• Eczema
• Epilepsy or seizures
• Hypotension (low blood stress)
• Liver illness
• Neuroleptic malignant syndrome (NMS)
• Peripheral edema (swelling of the fingers, ankles, or ft) 
• Psychosis (psychological sickness)
• Sleeping dysfunction
• End-stage kidney illness
• Glaucoma, angle-closure, untreated (narrow-angle glaucoma)
• Kidney illness

Proper Usage of Amantadine

For sufferers taking amantadine for Parkinson’s illness or motion issues (together with dyskinesia) attributable to sure medicines used to deal with nervous, psychological, and emotional situations:

• Take this medication precisely as directed by your physician. Do not take extra of it, don’t take it extra typically, and don’t take it for an extended time than your physician ordered.
• This medication comes with a Medication Guide or affected person info leaflet. Read and observe these directions rigorously. Ask your physician if in case you have any questions.
• Do not cease utilizing this medication all of a sudden with out asking your physician. You might have to slowly lower your dose earlier than stopping it utterly.
• Improvement within the signs of Parkinson’s illness normally happens in about 2 days. However, in some sufferers, this medication should be taken for as much as 2 weeks earlier than the complete profit is seen.

For sufferers taking amantadine to stop or deal with flu infections:

• Talk to your physician about the potential of getting a flu shot if in case you have not had one but.
• This medication is greatest taken earlier than publicity or instantly after publicity to individuals who have the flu.
• To assist preserve your self from getting the flu, preserve taking this medication for the complete time of remedy. Or if you have already got the flu, proceed taking this medication for the complete time of remedy even if you happen to start to really feel higher after just a few days. This will assist clear up your an infection utterly. If you cease taking this medication too quickly, your signs might return. This medication needs to be taken for at the very least 2 days after all of your flu signs have disappeared.
• This medication works greatest when there’s a fixed quantity within the blood. To assist preserve the quantity fixed, don’t miss any doses. Also, it’s best to take the doses at evenly spaced instances at day and evening. For instance, if you’re to take two doses a day, the doses needs to be spaced about 12 hours aside. If this interferes along with your sleep or different each day actions, or if you happen to want assist in planning the very best instances to take your medication, examine along with your physician.
• If you might be utilizing the oral liquid type of amantadine, use a marked measuring spoon, oral syringe, or medication cup to measure every dose appropriately. The common family teaspoon might not maintain the correct quantity of liquid.

Take Gocovri® extended-release capsule at bedtime. Swallow entire. Do not crush, break, or chew it. You may open and sprinkle the extended-release capsules on a teaspoonful of sentimental meals, together with applesauce. Take the entire medication instantly with out chewing. You might take this medication with or with out meals.

Take Osmolex ER™ extended-release pill within the morning. Swallow entire. Do not crush, open, or chew it. Do not obtain the nasal flu vaccine (stay attenuated influenza vaccine) whereas taking this medication. Do not drink alcohol if you are utilizing this medication.

How long can you take amantadine?

This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times at day and night.

Amantadine Dosage

The dose of this medication can be totally different for various sufferers. Follow your physician’s orders or the instructions on the label. The following info consists of solely the common doses of this medication. If your dose is totally different, don’t change it until your physician tells you to take action.

The quantity of medication that you simply take will depend on the energy of the medication. Also, the variety of doses you are taking every day, the time allowed between doses, and the size of time you are taking the medication rely on the medical drawback for which you might be utilizing the medication.

• For remedy of Parkinson’s illness or motion issues (together with dyskinesia):
  • For oral dosage varieties (extended-release capsules):
    • Adults: 137 milligrams (mg) as soon as a day at bedtime. Your physician might enhance your dose to 274 mg (two 137 mg capsules) as soon as a day at bedtime after one week.
    • Children: Use and dose should be decided by your physician.
  • For oral dosage varieties (extended-release tablets):
    • Adults: 129 milligrams (mg) as soon as a day within the morning. Your physician might enhance your dose every week to a most dose of 322 mg (one 129 mg pill and one 193 mg pill) as soon as a day taken within the morning.
    • Children: Use and dose should be decided by your physician.
  • For oral dosage varieties (liquid-filled capsules, syrup, and tablets):
    • Adults: 100 milligrams (mg) 2 instances a day. Your physician might alter your dose as wanted.
    • Older adults: At first, 100 milligrams (mg) as soon as a day as a single dose. Your physician might alter your dose as wanted.
    • Children: Use and dose should be decided by your physician.
• For the remedy or prevention of flu:
  • For oral dosage varieties (capsules, syrup, and tablets):
    • Adults: 200 milligrams (mg) or 4 teaspoonfuls as soon as a day as a single dose.
    • Older adults: 100 milligrams (mg) as soon as a day as a single dose.
    • Children 9 to 12 years of age: 100 milligrams (mg) or 2 teaspoonfuls 2 instances a day.
    • Children 1 to 9 years of age: Dose is predicated on physique weight and should be decided by your physician. The ordinary dose is 4.4 to eight.8 milligrams (mg) per kilogram (kg) of physique weight per day. The dose is split evenly and given 2 instances a day. However, the dose is normally no more than 150 mg per day.
    • Children youthful than 1 12 months of age: Use and dose should be decided by your physician.

Missed Dosage

If you miss a dose of this medication, take it as quickly as attainable. However, whether it is nearly time in your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses. If you miss a dose of amantidine, skip the missed dose and take your subsequent dose at your ordinary time. Do not take further medication to make up for a missed dose.

Do you need to wean off amantadine?

Amantadine should not be discontinued abruptly as it may cause NMS symptoms and higher doses of amantadine need to be gradually tapered for 1 to 2 weeks before discontinuation.

How long before amantadine is out of your system?

The half-life was 17 ± 4 hours (range: 10 to 25 hours). Across other studies, amantadine plasma half-life has averaged 16 ± 6 hours (range: 9 to 31 hours) in 19 healthy volunteers.

Symmetrel Storage

1. Store the medication in a closed container at room temperature, away from warmth, moisture, and direct gentle. Keep from freezing.
2. Keep out of the attain of youngsters.
3. Do not preserve outdated medication or medication now not wanted.
4. Ask your healthcare skilled how you need to eliminate any medication you don’t use.

Amantadine Precautions

It is essential that your physician examine your progress at common visits to see if the medication is working correctly and to permit adjustments in your dose. Blood and urine assessments could also be wanted to examine for any side effects.

• Amantadine might trigger some individuals to be agitated, irritable, or show different irregular behaviors. It may trigger some individuals to have suicidal ideas and tendencies or to change into extra depressed. Also inform your physician if in case you have sudden or robust emotions, comparable to feeling nervous, indignant, stressed, violent, or scared. If you, your little one, or your caregiver discover any of those antagonistic results, inform your physician or your kid’s physician instantly.
• Some individuals who have used this medication had uncommon adjustments of their habits. Talk along with your physician instantly if you happen to begin having uncommon urges, comparable to playing urges, binge or compulsive consuming, compulsive buying, or sexual urges whereas utilizing this medication.
• Drinking alcoholic drinks whereas taking this medication might trigger elevated uncomfortable side effects, comparable to circulation issues, dizziness, lightheadedness, fainting, or confusion. Do not drink alcoholic drinks if you are taking this medication.
• This medication might trigger some individuals to change into dizzy, drowsy, or lightheaded, or to have blurred imaginative and prescient or bother concentrating. Do not drive or do anything that could possibly be harmful till you understand how this medication impacts you.

Amantadine Side Effects

Along with its wanted results, a medication might trigger some negative effects. Although not all of those uncomfortable side effects might happen, in the event that they do happen they might want medical consideration.

Check along with your physician instantly if any of the next uncomfortable side effects happen:

• Bladder ache
• bloody or cloudy urine
• blurred imaginative and prescient
• confusion
• tough, burning, or painful urination
• dizziness or lightheadedness
• fainting
• falls
• frequent urge to urinate
• decrease again or facet ache
• seeing, listening to, or feeling issues that aren’t there
• swelling of the fingers, ft, or decrease legs

Other negative effects not listed can also happen in some sufferers. If you discover some other results, verify along with your healthcare skilled. Call your physician for medical recommendation about negative effects.

Does amantadine affect blood pressure?

Amantadine antagonizes the blood pressure responses evoked by electrical stimulation of the central and peripheral end of the vagus. Blood pressure responses on sympathetic stimulation are also attenuated. These results could be explained on the basis of a possible effect on autonomic ganglia.

Is Amantadine an antidepressant?

Amantadine blocks N-methyl-D-aspartate (NMDA) receptors and has dopaminergic and noradrenergic action, a neurochemical profile that suggests its potential as an antidepressant drug.

Is Amantadine a dopamine agonist?

Amantadine, a dopamine agonist is reported to act by releasing dopamine from the dopaminergic nerve terminals as an anti-Parkinsonian drug. In the present behavioural study in the rat, molindone-induced catalepsy and ptosis, which are dopamine dependent-behaviors are reversed by amantadine.

How does amantadine increase dopamine?

Amantadine increases the extracellular dopamine levels in the striatum by re-uptake inhibition and by N-methyl-D-aspartate antagonism.

Can you drink while taking amantadine?

Do not drink alcoholic beverages while you are taking this medicine. This medicine may cause some people to become dizzy, drowsy, or lightheaded, or to have blurred vision or trouble concentrating. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

How does amantadine work on Covid?

Amantadine by its lipophilic nature is able to cross the endosome membrane and interrupt the release of the virion into the cell. Similarly, amantadine may enter the E-channel of the coronavirus preventing the release of the viral nucleus into the cell.

Can humans take amantadine?

It has not been confirmed that amantadine is safe and effective for use in people younger than 18 years. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, an increased amount of a drug stays in your body for a longer time.

Disclaimer

Information concerning psychotic disorders, included within the review of Amantadine, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.