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What is naproxen?

There are two types of prescription naproxen: Generic Naproxen and naproxen sodium. Regular naproxen comes as an oral immediate-release tablet, an oral delayed-release tablet, and an oral suspension. Naproxen sodium comes as an oral immediate-release tablet and an oral extended-release tablet.

Naproxen is also available in over-the-counter forms. This article only addresses prescription forms of naproxen.

Prescription naproxen oral tablets are available as the brand-name drugs Anaprox, Naprelan, and Naprosyn. They’re also available as generic drugs. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Dosage

Read the Medication Guide provided by your pharmacist before you start using naproxen and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually twice daily with or without food. Swallow this medication whole. Do not break, crush, or chew the tablets. Doing so can release the drug too quickly, increasing the risk of side effects. Take this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug.

The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed. For ongoing conditions such as arthritis, continue taking this medication as directed by your doctor.

The quantity of drugs that you simply take relies on the power of the drugs. Also, the variety of doses you’re taking every day, the time allowed between doses, and the size of time you’re taking the drugs depend upon the medical downside for which you’re utilizing the drugs.

• For Naproxen Naprosyn® pill and oral suspension dosage types:
  • For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis:
    • Adults: At first, 250 milligrams (mg) (10 milliliters (mL)/2 teaspoonfuls), 375 mg (15 mL/3 teaspoonfuls), or 500 mg (20 mL/4 teaspoonfuls) 2 occasions a day, within the morning and night. Your physician might alter your dose as wanted. However the dose is normally no more than 1500 mg per day.
    • Children 2 years of age and older: Dose is predicated on physique weight and have to be decided by your physician. The dose is normally 5 milligrams (mg) per kilogram (kg) of physique weight 2 occasions a day.
    • Children youthful than 2 years of age: Use and dose have to be decided by your physician.
  • For acute gout:
    • Adults: 750 milligrams (mg) for the primary dose, then 250 mg each 8 hours till the assault is relieved.
    • Children: Use and dose have to be decided by your physician.
• For naproxen controlled-release pill (eg, Naprelan®) dosage kind:
  • For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis:
    • Adults: At first, 750 milligrams (mg) (taken as one 750 mg or two 375 mg tablets) or 1000 mg (taken as two 500 mg tablets) as soon as a day. Your physician might alter your dose as wanted. However the dose is normally no more than 1500 mg (taken as two 750 mg or three 500 mg tablets) per day.
    • Children: Use and dose have to be decided by your physician.
  • For bursitis, tendinitis, menstrual cramps, and different kinds of ache:
    • Adults: At first, 1000 milligrams (mg) (taken as two 500 mg tablets) as soon as a day. Some sufferers may have 1500 mg (taken as two 750 mg or three 500 mg tablets) per day, for a restricted interval. However, the dose is normally no more than 1000 mg per day.
    • Children: Use and dose have to be decided by your physician.
  • For acute gout:
    • Adults: 1000 to 1500 milligrams (mg) (taken as two to 3 500 mg tablets) as soon as a day for the primary dose, then 1000 mg (taken as two 500 mg tablets) as soon as a day till the assault is relieved.
    • Children: Use and dose have to be decided by your physician.
• For naproxen delayed-release pill (eg, EC-Naprosyn®) dosage kind:
  • For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis:
    • Adults: At first, 375 or 500 milligrams (mg) 2 occasions a day, within the morning and night. Your physician might alter the dose as wanted. However, the dose is normally no more than 1500 mg per day.
    • Children: Use and dose have to be decided by your physician.
• For Aleve naproxen sodium (eg, Anaprox®, Anaprox® DS) pill dosage kind:
  • For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis:
    • Adults: At first, 275 or 550 milligrams (mg) 2 occasions a day, within the morning and night. Your physician might alter the dose as wanted. However, the dose is normally no more than 1500 mg per day.
    • Children: Use and dose have to be decided by your physician.
  • For bursitis, tendinitis, menstrual cramps, and different kinds of ache:
    • Adults: 550 milligrams (mg) for the primary dose, then 550 mg each 12 hours or 275 mg each 6 to eight hours as wanted. Your physician might alter the dose as wanted. However, the dose is normally no more than 1375 mg per day.
    • Children: Use and dose have to be decided by your physician.
  • For acute gout:
    • Adults: 825 milligrams (mg) for the primary dose, then 275 mg each 8 hours till the assault is relieved.
    • Children: Use and dose have to be decided by your physician.

For certain conditions (such as arthritis), it may take up to two weeks of taking this drug regularly until you get the full benefit.

Side Effects

Prescription naproxen oral tablets may cause drowsiness. You shouldn’t drive, use machinery, or do other activities that require alertness until you know you can function normally. This drug can also cause other side effects.

More common side effects

The more common side effects that occur with naproxen oral tablet include:

• stomach pain
• constipation
• diarrhea
• gas
• heartburn
• nausea and vomiting
• dizziness

Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• chest pain
• shortness of breath or trouble breathing
• weakness in one part or side of your body
• difficulty speaking
• swelling of the face or throat
• high blood pressure
• bleeding and ulcers in your stomach and intestines, with symptoms such as:
  • stomach pain
  • bloody vomit
  • blood in your stool
  • black and sticky stool
  • asthma attacks in people who have asthma
  • low red blood cell count, which can cause fatigue, lethargy, and weakness
  • yellowing of your skin or the whites of your eyes
  • unusual weight gain or swelling of your arms, legs, hands, and feet
  • skin rash or blisters with fever

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Precautions

Before taking naproxen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), blood disorders (such as anemia, bleeding/clotting problems), growths in the nose (nasal polyps), heart disease (such as previous heart attack), high blood pressure, liver disease, stroke, throat/stomach/intestinal problems (such as bleeding, heartburn, ulcers).

• Kidney problems can sometimes occur with the use of NSAID medications, including naproxen. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.
• This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).
• This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.
• This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.
• Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
• Older adults may be at greater risk for stomach/intestinal bleeding, kidney problems, heart attack, and stroke while using this drug.
• Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks. Tell your doctor if you are pregnant or if you plan to become pregnant. This medication may harm an unborn baby and cause problems with normal labor/delivery. It is not recommended for use in pregnancy from 20 weeks until delivery. If your doctor decides that you need to use this medication between 20 and 30 weeks of pregnancy, you should use the lowest effective dose for the shortest possible time. You should not use this medication after 30 weeks of pregnancy.
• This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Products that may interact with this drug include aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), cidofovir, corticosteroids (such as prednisone), lithium, “water pills” (diuretics such as furosemide).

Do not take this medication with antacids or other drugs that decrease stomach acid (including famotidine, ranitidine, proton pump inhibitors such as omeprazole). These products may affect the enteric coating of this drug, causing the medication to be released too quickly and increasing the risk of side effects.

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, “blood thinners” such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as celecoxib, ibuprofen, or ketorolac). These drugs are similar to naproxen and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Daily use of naproxen may decrease aspirin’s ability to prevent heart attack/stroke. Talk with your doctor about the risks and benefits. Ask about other medications that can be used to treat pain/fever.

Overdose

You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• fatigue
• drowsiness
• upset stomach
• heartburn
• nausea and vomiting
• loss of consciousness
• stomach bleeding

In rare cases, an overdose can cause:

• dangerous allergic reactions
• high blood pressure
• kidney failure
• trouble breathing
• coma

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

Missed Dose

If you miss your dose, take it as soon as you can. However, if it’s just a few hours until your next dose, wait until the scheduled time and take a single dose. Never try to catch up by taking two doses at once. This could result in toxic side effects.

Storage

Store naproxen at room temperature between 68°F and 77°F (20°C and 25°C). Keep the container tightly closed and protect the drug from light.