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What is Glimepiride?

Glimepiride is a prescription drug. It comes as an oral pill. It is the accessible because the brand-name drug Amaryl and as a generic drug. Generic medication often value much less. In some circumstances, they will not be obtainable in each power or kind because the brand-name model.

This drug could also be used as a part of a mixture remedy. That means you have to take it with different medication.

Amaryl Dosage

Read the Patient Information Leaflet if obtainable out of your pharmacist earlier than you begin taking glimepiride and every time you get a refill. If you could have any questions, ask your physician or pharmacist.

  • Take this treatment by mouth with breakfast or the primary essential meal of the day, as directed by your physician, often as soon as day by day. The dosage is predicated in your medical situation and response to therapy.
  • Use this treatment usually to get essentially the most profit from it. To enable you to bear in mind, take it on the similar time every day.
  • To scale back your danger of unwanted side effects, your physician could direct you to start out this treatment at a low dose and steadily enhance your dose. Follow your physician’s directions fastidiously.
  • If you’re already taking one other diabetes drug (resembling chlorpropamide), observe your physician’s instructions fastidiously for stopping the outdated drug and beginning glimepiride.
  • Colesevelam can lower the absorption of glimepiride. If you’re taking colesevelam, take glimepiride not less than 4 hours earlier than taking colesevelam.
  • Tell your physician in case your situation doesn’t enhance or if it worsens (your blood sugar is simply too excessive or too low).

All potential dosages and kinds will not be included right here. Your dose, kind, and the way usually you’re taking it can rely upon:

  • your age
  • the situation being handled
  • how extreme your situation is
  • different medical situations you could have
  • the way you react to the primary dose

Glimepiride Side Effects

Glimepiride oral pill doesn’t trigger drowsiness, however it will possibly trigger different unwanted side effects.

More widespread unwanted Amaryl side effects

The extra widespread unwanted side effects that may happen with glimepiride embody:

  • low blood sugar (hypoglycemia). Symptoms could embody:
    • trembling or shaking
    • nervousness or nervousness
    • irritability
    • sweating
    • lightheadedness or dizziness
    • headache
    • quick coronary heart fee or palpitations
    • intense starvation
    • fatigue or tiredness
  • headache
  • nausea
  • dizziness
  • weak spot
  • unexplained weight achieve

If these results are gentle, they might go away inside a number of days or a few weeks. If they’re extra extreme or don’t go away, discuss to your physician or pharmacist.

What to do if you are experiencing unwanted Side Effects

Call your physician straight away when you’ve got critical unwanted side effects. Call 911 in case your signs really feel life-threatening or should you suppose you’re having a medical emergency. Serious unwanted side effects and their signs can embody the next:

  • extreme low blood sugar (lower than 35 to 40 mg/dL). Symptoms could embody:
    • temper modifications, resembling irritability, impatience, anger, stubbornness, or disappointment
    • confusion, together with delirium
    • lightheadedness or dizziness
    • sleepiness
    • blurred or impaired imaginative and prescient
    • tingling or numbness in your lips or tongue
    • complications
    • weak spot or fatigue
    • lack of coordination
    • nightmares or crying out in your sleep
    • seizures
    • unconsciousness
  • hypersensitivity (allergic) reactions. This drug could cause a number of forms of allergic reactions, together with:
    • anaphylaxis. This is a extreme and presumably a life-threatening allergic response. Symptoms could embody bother respiration, swelling of your throat or tongue, hives, or issue swallowing.
    • angioedema. This includes swelling of your pores and skin, the layers below your pores and skin, and your mucous membranes (inside your mouth).
    • Stevens-Johnsons syndrome. This is a uncommon and critical dysfunction of your pores and skin and mucous membranes (mouth and nostril). It begins with flu-like signs and is adopted by a painful crimson rash and blisters.
  • liver injury. Symptoms could embody:
    • yellowing of your pores and skin and the whites of your eyes (jaundice)
    • abdomen ache and swelling
    • swelling in your legs and ankles (edema)
    • itchy pores and skin
    • dark-colored urine
    • pale stool or tar-colored stool
    • fixed sleepiness
    • nausea
    • vomiting
    • bruising simply
  • low blood cell or platelet counts. Symptoms could embody infections and bruising or bleeding that doesn’t cease as rapidly as regular.
  • low sodium ranges (hyponatremia) and syndrome of inappropriate antidiuretic hormone secretion (SIADH). In SIADH, your physique is unable to eliminate extra water by urinating. This results in decrease sodium ranges in your blood (hyponatremia), which is harmful. Symptoms could embody:
    • nausea and vomiting
    • headache
    • confusion
    • lack of vitality and fatigue
    • restlessness and irritability
    • muscle weak spot, spasms, or cramps
    • seizures
    • coma


Before taking glimepiride, inform your physician or pharmacist if you’re allergic to it; or when you’ve got every other allergic reactions. This product could comprise inactive elements, which might trigger allergic reactions or different issues. Talk to your pharmacist for extra particulars.

Take note that always utilizing this treatment, inform your physician or pharmacist your medical historical past, particularly of: liver illness, kidney illness, thyroid illness, sure hormonal situations (adrenal/pituitary insufficiency, syndrome of inappropriate secretion of antidiuretic hormone-SIADH), electrolyte imbalance (hyponatremia).

You could expertise blurred imaginative and prescient, dizziness, or drowsiness on account of extraordinarily low or excessive blood sugar. Do not drive, use equipment, or do any exercise that requires alertness or clear imaginative and prescient till you’re positive you possibly can carry out such actions safely.

  • Limit alcohol whereas taking this treatment as a result of it will possibly enhance your danger of growing low blood sugar.
  • It could also be more durable to regulate your blood sugar when your physique is harassed (resembling on account of fever, an infection, harm, or surgical procedure). Consult your physician as a result of this will require a change in your therapy plan, medicines, or blood sugar testing.
  • This treatment could make you extra delicate to the solar. Limit your time within the solar. Avoid tanning cubicles and sunlamps. Use sunscreen and put on protecting clothes when open air. Tell your physician straight away should you get sunburned or have pores and skin blisters/redness.
  • Before having surgical procedure, inform your physician or dentist about all of the merchandise you utilize (together with pharmaceuticals, nonprescription medication, and natural merchandise).
  • Older adults could also be extra delicate to the unwanted side effects of this drug, particularly low blood sugar.

During being pregnant, this treatment needs to be used solely when clearly wanted. Pregnancy could trigger or worsen diabetes. Discuss a plan along with your physician for managing your blood sugar whereas pregnant. Your physician could substitute insulin for this drug throughout being pregnant. If glimepiride is used, it might be switched to insulin not less than 2 weeks earlier than the anticipated supply date due to glimepiride’s danger of inflicting low blood sugar in your new child. Discuss the dangers and advantages along with your physician.

It is unknown if this treatment passes into breast milk. However, comparable medication go into breast milk. Breast-feeding whereas utilizing this treatment isn’t beneficial. Consult your physician earlier than breastfeeding.


Drug interactions could change how your medicines work or enhance your danger for critical unwanted side effects. This doc doesn’t comprise all potential drug interactions. Keep an inventory of all of the merchandise you utilize (together with prescription/nonprescription medication and natural merchandise) and share it along with your physician and pharmacist. Do not begin, cease, or change the dosage of any medicines with out your physician’s approval.

Many medication can have an effect on your blood sugar, making it more durable to regulate. Before you begin, cease, or change any treatment, discuss along with your physician or pharmacist about how the treatment could have an effect on your blood sugar. Check your blood sugar usually as directed and share the outcomes along with your physician. Tell your physician straight away when you’ve got signs of excessive or low blood sugar. (See additionally Side Effects part.) Your physician may have to regulate your diabetes treatment, train program, or weight loss plan.

Beta-blocker medicines (together with metoprolol, propranolol, glaucoma eye drops resembling timolol) could forestall the quick/pounding heartbeat you’ll often really feel when your blood sugar falls too low (hypoglycemia). Other signs of low blood sugar resembling dizziness, starvation, or sweating are unaffected by these medication.

Check the labels on all of your medicines (resembling cough-and-cold merchandise) as a result of they might comprise elements that would have an effect on your blood sugar. Ask your pharmacist about utilizing these merchandise safely.

Glimepiride Overdose

If you’re taking an excessive amount of glimepiride, monitor your blood sugar very carefully and start therapy in case your blood sugar falls under 70 mg/dL. If this occurs, take 15 to twenty grams of glucose (a sort of sugar). You must eat or drink one of many following:

  • 3 to 4 glucose tablets
  • a tube of glucose gel
  • ½ cup of juice or common, non-diet soda
  • 1 cup of nonfat or 1 p.c cow’s milk
  • 1 tablespoon of sugar, honey, or corn syrup
  • 8 to 10 items of exhausting sweet, resembling lifesavers
  • Test your blood sugar quarter-hour after you deal with the low sugar response. If your blood sugar remains to be low, then repeat the above therapy.
  • Once your blood sugar is again within the regular vary, eat a small snack in case your subsequent deliberate meal or snack is greater than 1 hour later.

If you don’t deal with low blood sugar, you possibly can have a seizure, go out, and presumably develop mind injury. Low blood sugar may even be deadly.

When you go out due to a low sugar response or can not swallow, somebody should offer you an injection of glucagon to deal with the low sugar response. You could must go to the emergency room.

Glimepiride Missed Dose

If you neglect to take your dose, take it as quickly as you bear in mind. If it’s only a few hours earlier than the time to your subsequent dose, solely take one dose. Never attempt to catch up by taking two doses without delay. This might lead to extreme unwanted side effects, resembling low blood sugar.


How to store Amaryl Glimepiride

  • Store at room temperature away from gentle and moisture.
  • Do not retailer within the rest room. Keep all medicines away from youngsters and pets.
  • Do not flush medicines down the bathroom or pour them right into a drain except instructed to take action.
  • Properly discard this product when it’s expired or not wanted.
  • Consult your pharmacist or native waste disposal firm.

Disclaimer of legal responsibility

Pfizer isn’t affiliated with this web site. The model title and logos and pictures used are the property of Pfizer. The content material of this web site is for informational functions solely. We don’t provide, market or ship medicines ourselves and refer you to respected net shops on the Internet. Always seek the advice of a doctor when utilizing medicines.

On this web site we don’t promote any medicines and refer guests to trusted Internet suppliers. In this fashion, we prevent and the very best worth to folks many issues and you’ll simply and legally acquire this highly effective medication.

Frequently requested questions

  • What is Glimepiride?

    Glimepiride is available as the brand-name drug Amaryl and as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.

  • What to do if you miss a dose?

    If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at a regular time. Do not double the dose to catch up.

  • What if u take too much Glimepiride?

    If an overdose happens call the emergency center. You might have pressing medical care. You might also a Poison Control Center immediately.

  • How to store Glimepiride?

    Store this drug at room temperature. Keep it, below 25°C (77°F) and out of reach and children and pets.

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Last Updated on October 3, 2021 by Toni El Clikos

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