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What is Pioglitazone?

Metformin/pioglitazone is a drugs that requires a prescription. There are two forms of oral immediate-release tablets: oral immediate-release tablets and oral extended-release tablets.

Actoplus Met (immediate-release) and Actoplus with XR are brand-name medicines that comprise metformin and pioglitazone (extended-release). A generic model of the immediate-release capsule can also be obtainable. Generic medicines are regularly cheaper than their brand-name counterparts. They will not be accessible in each energy or kind as brand-name medicines in some circumstances.

Metformin/pioglitazone is a single-dose mixture of two medicines. It’s crucial to grasp all the medicines within the combo as a result of every one could have a definite impact on you.

Combination remedy with metformin and pioglitazone is an choice. That means you will have to mix it with different medicines.


Before you begin taking Actos pioglitazone, and each time you get a refill, learn the Medication Guide issued by your pharmacist. Inquire together with your physician or pharmacist in case you have any issues.

Take this medicine by mouth as soon as a you start the day, with or with out meals, as instructed by your physician. The dosage is decided by your medical situation, response to remedy, and whether or not or not you take some other diabetes medicines. To uncover the suitable dose for you, your physician will change your medicine based mostly in your blood sugar. Follow your physician’s directions to the letter.

To obtain one of the best profit from this drug, take it each day. It’s vital to recollect to make use of it on the similar time day by day.

If you are already taking a diabetes medicine (resembling metformin or a sulfonylurea), fastidiously comply with your physician’s directions for stopping/persevering with the previous one and beginning this one. Follow your physician’s medicine remedy routine, meals plan, and train program to the letter.

As suggested by your physician, test your blood sugar on a frequent foundation. Keep observe of your findings and inform your physician. If your blood sugar ranges are abnormally excessive or low, inform your physician. It’s doable that your dosage or remedy will have to be adjusted. The whole advantage of this medication could take as much as 2 to three months to manifest.

It’s conceivable that not all doses and types are lined. The following components will affect the dose, kind, and frequency with which you are taking it:

  • your age
  • the situation being handled
  • how extreme your situation is
  • different medical situations you may have
  • the way you react to the primary dose

Actos Side Effects

Drowsiness shouldn’t be brought on by metformin/pioglitazone oral pill. It could, nonetheless, induce low blood sugar and different destructive results.

More frequent unwanted side effects

The extra frequent unwanted side effects that happen with metformin/pioglitazone embrace:

  • diarrhea
  • nausea
  • upset abdomen
  • cold-like signs (higher respiratory tract an infection)
  • swelling in your legs, ankles, or toes (edema)
  • headache
  • weight acquire

If the antagonistic results are modest, they need to go away in a couple of days or perhaps weeks. If they get extra extreme or don’t go away, seek the advice of your physician or pharmacist.

Serious unwanted side effects

If you expertise any main unwanted side effects, contact your physician straight as soon as. If your signs are life-threatening otherwise you imagine you’re having a medical emergency, dial the emergency number. The following are examples of great unwanted side effects and related signs:

  • Low blood sugar (hypoglycemia).* Symptoms can embrace:
    • temper adjustments, resembling irritability, anger, or disappointment
    • confusion
    • lightheadedness
    • dizziness
    • sleepiness
    • blurred imaginative and prescient
    • tingling or numbness in your lips or tongue
    • complications
    • weak spot
    • tiredness
    • lack of coordination
    • nightmares or crying out throughout your sleep
    • seizures
    • lack of consciousness
  • Lactic acidosis. Symptoms can embrace:
    • weak spot or tiredness
    • uncommon muscle ache
    • abdomen pains, nausea, or vomiting
    • bother respiration
    • dizziness or lightheadedness
    • gradual or irregular coronary heart charge
  • Heart failure. Symptoms can embrace:
    • swelling or fluid retention, particularly in your ankles or legs
    • shortness of breath or bother respiration, particularly while you lie down
    • unusually quick weight acquire
    • uncommon tiredness
  • Macular edema (swelling behind your eye). Symptoms can embrace:
    • blurred imaginative and prescient
  • Anemia (low crimson blood cell depend). Symptoms can embrace:
    • pale pores and skin
    • shortness of breath
    • tiredness
    • chest ache
  • Bladder most cancers. Symptoms can embrace:
    • blood in your urine
    • needing to urinate extra typically than regular
    • ache in your bladder while you urinate
  • Broken bones (fractures)
  • Ovulation, which can result in being pregnant

Treating low blood sugar

*If you may have a low blood sugar response, that you must deal with it.

  • For gentle hypoglycemia (55–70 mg/dL), remedy is 15–20 grams of glucose (a kind of sugar). You have to eat or drink one of many following:
    • 3–4 glucose tablets
    • a tube of glucose gel
    • ½ cup of juice or common, non-diet soda
    • 1 cup of nonfat or 1% cow’s milk
    • 1 tablespoon of sugar, honey, or corn syrup
    • 8–10 items of laborious sweet, resembling lifesavers
  • Test your blood sugar quarter-hour after you deal with the low sugar response. If your blood sugar remains to be low, repeat the above remedy.
  • Once your blood sugar is again within the regular vary, eat a small snack in case your subsequent deliberate meal or snack is greater than 1 hour later.

You can have a seizure, move out, and maybe endure mind injury in case you do not handle low blood sugar. Low blood sugar has the potential to be deadly. If you move unconscious or cannot swallow as a consequence of a low sugar response, somebody must inject you with glucagon to remedy the low sugar response. It’s doable that you will have to go to the emergency room.

Pioglitazone Actos Precautions

If you’re allergic to pioglitazone or have some other allergic reactions, notify your physician or pharmacist earlier than taking it. Inactive chemical compounds could also be included on this product, inflicting allergic reactions or different points. For additional info, communicate together with your pharmacist.

Tell your physician or pharmacist in case you have ever had coronary heart issues (resembling congestive coronary heart failure or chest ache), liver illness, fluid in your lungs, swelling (edema), anemia, a selected eye situation (macular edema), or bladder most cancers earlier than utilizing this drug.

You could expertise blurred imaginative and prescient, dizziness, or drowsiness in case your blood sugar is both low or too excessive. Do not drive, function equipment, or have interaction in some other exercise that requires alertness or clear imaginative and prescient till you’re assured that you are able to do so safely. Alcohol ought to be prevented when taking this medicine because it will increase the danger of low blood sugar.

When your physique is harassed, controlling your blood sugar could also be tougher (resembling as a consequence of fever, an infection, harm, or surgical procedure). Increased stress could necessitate a change in your remedy plan, medicines, or blood sugar assessments, so discuss to your physician.

Tell your physician or dentist about all the belongings you use (together with prescription prescribed drugs, over-the-counter medicines, and natural treatments) earlier than surgical procedure.

In girls, pioglitazone could improve the danger of bone fracture (often within the higher arm, hand, or foot). Also see the Notes part.

Pioglitazone can alter your menstrual cycle (promote ovulation) and improve your possibilities of getting pregnant. While taking this medicine, discuss to your physician or pharmacist about utilizing a dependable contraception technique.

During being pregnant, this medication ought to solely be used when completely mandatory. Consult your physician concerning the risks and benefits. During your being pregnant, your physician could substitute insulin for this medicine. Pay shut consideration to all the instructions.

It is unknown if this medicine goes into breast milk. Before you begin breastfeeding, discuss to your physician.


Drug interactions could cause your prescriptions to carry out in another way or put you in danger for harmful antagonistic results. This record doesn’t embrace all potential medicine interactions. Keep a listing of all the things you utilize (together with prescription and nonprescription prescribed drugs, in addition to natural merchandise) and focus on it together with your physician and pharmacist. Without your physician’s permission, don’t start, cease, or modify the dosage of any medicines.

Other medication could intrude with the clearance of pioglitazone out of your physique, inflicting pioglitazone to function in another way. Gemfibrozil, rifamycins, together with rifampin, are only some examples.

Beta-blocker medication (resembling metoprolol, propranolol, and glaucoma eye drops like timolol) may help you keep away from the quick, pounding heartbeat that happens when your blood sugar goes too low (hypoglycemia). These medicines have little impact on different signs of low blood sugar, resembling dizziness, starvation, or sweating.

Many medicines might need an antagonistic impact in your blood sugar, making it tougher to handle. Consult your physician or pharmacist earlier than starting, stopping, or altering any medicine to be taught the way it could affect your blood sugar. Check your blood sugar as prescribed and inform your physician of the outcomes. If you may have signs of excessive or low blood sugar, name your physician straight as soon as. (See additionally the part on Side Effects.) Your diabetic medicine, train routine, or weight loss program could have to be adjusted by your physician.


Low blood sugar can happen in case you take an excessive amount of metformin/pioglitazone. You ought to deal with your low blood sugar in case you worry you’ve got taken an excessive amount of of this medicine or in case you’re experiencing signs of low blood sugar.

Missed Dose

Take metformin/pioglitazone as quickly as you bear in mind in case you miss a dose. If you simply have a couple of hours earlier than your subsequent dose, solely take one capsule at the moment.

Pioglitazone Storage

  • Store metformin/pioglitazone at room temperature between 59°F and 86°F (15°C and 30°C).
  • Keep the bottle utterly closed and the tablets dry always.
  • Don’t freeze this drug.
  • Don’t retailer this medicine in moist or damp areas, resembling loos.

Disclaimer of legal responsibility

Pfizer shouldn’t be affiliated with this website. The model identify and logos and pictures used are the property of Pfizer. The content material of this website is for informational functions solely. We don’t provide, market or ship medicines ourselves and refer you to respected internet shops on the Internet. Always seek the advice of a doctor when utilizing medicines.

On this web site we don’t promote any medicines and refer guests to trusted Internet suppliers. In this manner, we prevent and one of the best value to individuals many issues and you may simply and legally acquire this highly effective medication.

Frequently requested questions

  • What is Pioglitazone?

    Actoplus Met (immediate-release) and Actoplus Met XR are brand-name medicines that contain metformin and pioglitazone (extended-release). A generic version of the immediate-release pill is also available. Generic medications are frequently less expensive than their brand-name counterparts.

  • What if u take too much Pioglitazone?

    If you take too much metformin/pioglitazone, you may experience low blood sugar. If you think that you’ve taken too much of this medication or have symptoms of low blood sugar, you need to treat your low blood sugar (see above).

  • What to do if you miss a dose?

    Take metformin/pioglitazone as soon as you remember if you miss a dose. If you just have a few hours before your next dose, only take one pill at that time.

  • What if u take too much Pioglitazone?

    If an overdose happens call the emergency center. You might have pressing medical care. You might also a Poison Control Center immediately.

  • How to store Pioglitazone?

    Store this drug at room temperature. Keep it, below 15 C -30 C (59 F -86 F) and out of reach and children and pets.

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Last Updated on August 29, 2021 by Toni El Clikos

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