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Active Ingredient: Tofranil
Brand(s): Imipramine

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What is Imipramine Generic?

Imipramine Tofranil Generic is an irregular antipsychotic medicine. Blocks dopamine receptors of CNS as well as conflicts dopamine button in basic gangliya as well as in limbic a component of neoncephalon. It is taken at hypersensitivity, disorders of hemopoietic system (along with in anamnesis), alcoholic as well as harmful psychosis, myasthenia, comas.

Tofranil Generic Drug Uses

  1. Imipramine is used to deal with:
    • Melancholy that’s longer lasting and/or extra extreme than the “low moods” that everybody has every now and then because of the stress of on a regular basis life. It’s considered attributable to a chemical imbalance in components of the mind. This imbalance impacts your complete physique and may trigger emotional and bodily signs akin to feeling low in spirit, lack of curiosity in actions, being unable to take pleasure in life, poor urge for food or overeating, disturbed sleep, lack of intercourse drive, lack of vitality and feeling responsible over nothing.
    • Mattress-wetting in individuals from the age of 5 years onwards if there isn’t any bodily trigger for the issue (i.e. there may be nothing fallacious with the bladder itself).
  2. Imipramine belongs to a bunch of medicines referred to as tricyclic antidepressants (TCAs).
  3. Imipramine corrects this chemical imbalance and should assist relieve the signs of despair.

Ask your physician in case you have any questions on why this medication has been prescribed for you. Your physician could have prescribed it for an additional goal.

What Should You Discuss To Your Doctor Before Using This Medicine

  • Don’t take Imipramine in case you have ever had an allergic response after taking:
    • imipramine (the lively ingredient in Tofranil)
    • any of the opposite substances listed on the finish of this leaflet
    • some other tricyclic antidepressant.
    • A few of the signs of an allergic response could embrace:
      • shortness of breath, wheezing or problem respiration
      • swelling of the face, lips, tongue or different components of the physique
      • rash, itching or hives on the pores and skin.
  • Don’t begin taking Imipramine if you’re already taking one other medication referred to as a monoamine- oxidase inhibitor (MAOI) or you’ve been taking it throughout the previous 2 weeks.
    • Taking this medication along with a MAOI could trigger a critical response with a sudden improve in physique temperature, extraordinarily hypertension and seizures (suits). Your physician will know when it’s protected to begin Imipramine after the MAOI has been stopped.
  • Don’t take Tofranil if you’re recovering from a current coronary heart assault.
    • It might make your situation worse.
  • Don’t take Imipramine if you’re underneath 18 years of age for the remedy of despair or different psychiatric problems.
    • There may be not sufficient data to advocate the usage of this medication to deal with despair or different psychiatric problems in kids underneath 18 years of age.
  • Don’t take this medication after the expiry date printed on the pack or if the packaging is torn or reveals indicators of tampering.

If you’re unsure whether or not it’s best to begin taking Imipramine, discuss to your physician.

Things you need to inform to your physician

  • Inform your physician in case you have any of the next well being issues/medical circumstances:
    • coronary heart issues, particularly an irregular coronary heart beat
    • elevated stress within the eye from any trigger (e.g. glaucoma)
    • problem in passing urine (water), as a result of prostate bother or some other trigger
    • seizures (suits)
    • extreme liver or kidney illness
    • psychological problems aside from despair
    • issues with blood stress (both too excessive or too low)
    • blood problems
    • thyroid issues
    • persistent constipation
    • a tumour of the adrenal gland.
  • Inform your physician if you’re pregnant or intend to grow to be pregnant.
    • This medication could have an effect on your child if you happen to take it while you’re pregnant, particularly over the past 7 weeks of being pregnant. Your child could have some negative effects from the medication in the course of the first month after delivery.
  • Inform your physician if you’re breastfeeding or plan to breastfeed.
    • Breastfeeding isn’t really helpful while you’re taking Imipramine. The lively ingredient passes into the breast milk and will have an effect on your child.
  • Inform your physician if you happen to smoke.
    • Nicotine can have an effect on the quantity of Imipramine that’s in your physique. Sudden modifications in your normal smoking habits can even change the results of Tofranil.
  • Inform your physician if you’re allergic to some other medicines, meals, dyes or preservatives.
    • Your physician will wish to know if you’re liable to allergic reactions.
  • Inform your physician in case you have an intolerance to lactose or sucrose.
    • This medication comprises lactose and sucrose.

Imipramine Drug Interactions

Inform your physician or pharmacist if you’re taking some other medicines, together with any that you just purchase and not using a prescription from a pharmacy, grocery store or well being meals store. Some medicines and Tofranil could intervene with one another. These embrace:

  • MAOI medicines. You should not take Imipramine along with a MAOI (see “When you could not take it”)
  • medicines for hypertension or coronary heart issues
  • medicines that will help you sleep or calm you down
  • different medicines for despair referred to as SSRIs (e.g. fluoxetine and paroxetine)
  • medicines for different psychological problems
  • medicines for seizures (suits)
  • medicines to forestall blood clots (e.g. warfarin)
  • some medicines for colds or allergic reactions, together with some nostril drops
  • anticholinergic medicines, that are used to alleviate abdomen cramps, spasms and journey illness
  • medicines for thyroid issues
  • cimetidine, a medication for abdomen ulcers
  • sulfamethoxazole and trimethoprim, medicines used to deal with bacterial infections
  • terbinafine, a medication to deal with fungal infections
  • medicines for Parkinson’s illness
  • oestrogens (e.g. contraception drugs, hormone alternative remedy)
  • nicotine in medicines used that will help you stop smoking, akin to nicotine patches or chewing gum
  • methylphenidate (Ritalin)
  • disulfiram, a medication for alcoholism.

These medicines could also be affected by Tofranil or they might have an effect on how nicely it really works. You might have to take completely different quantities of your medicines or you could have to take completely different medicines. Your physician and pharmacist have extra data on medicines to watch out with or keep away from while you’re taking Imipramine.

Proper Usage of Imipramine Generic

  1. For despair, take the tablets in 2 or 3 doses unfold over the day except your physician advises you in any other case. If the tablets make you sleepy, your physician could recommend that you just take one dose at night time that will help you sleep nicely.
  2. For bed-wetting, take the tablets as a single dose after the night meal except your physician advises you in any other case. If bed-wetting tends to occur early within the night time, your physician could advise you to participate of the dose earlier (e.g. at 4 p.m.).
  3. Swallow the tablets with a full glass of water. In case your abdomen is upset after taking the tablets, take them with a meal or after a snack.
  4. Take this medication till your physician tells you to cease remedy. The size of remedy will rely in your situation and on how nicely the medication works.
  5. For bed-wetting, the remedy is normally continued for 1 to three months.

Imipramine Generic Dosage

Observe all instructions given to you by your physician and pharmacist fastidiously. They could differ from the knowledge contained on this leaflet. If you don’t perceive the directions on the label, ask your physician or pharmacist for assist.

For despair, remedy is normally began with a low dose (e.g. as much as 75 mg every day). The dose could be elevated slowly over the primary week as much as 150 to 200 mg every day.

  • In case your signs are very extreme, as much as 300 mg every day could also be prescribed.
  • Some individuals will want greater doses than others as a result of every individual’s physique chemistry is completely different.
  • As soon as you’re feeling higher, your physician could possibly slowly scale back the dose, normally right down to 50 to 100 mg every day.

For bed-wetting, the same old dose for kids aged 5-8 years is 20 to 30 mg every day. For youngsters aged 9-12 years the dose is 25 to 50 mg every day, and for kids aged over 12 years, the dose is as much as 75 mg every day. The upper doses are normally used if bed-wetting doesn’t enhance after every week of remedy at a decrease dose.

If you’re older than 65 years, your physician will in all probability begin with a low dose (e.g. 10 mg every day) to assist keep away from negative effects. The dose is steadily elevated over about ten days to 30 to 50 mg every day and stored at that dose for the remainder of your remedy.

Missed Dosage

  • In case you usually take the tablets 2 or 3 occasions a day and it’s virtually time to your subsequent dose (e.g. inside 2 or 3 hours), skip the dose you missed and take the subsequent one if you find yourself meant to. In any other case, take it as quickly as you keep in mind, after which return to taking the tablets as you’d usually.
  • In case you usually take the tablets solely at bedtime and also you miss a dose, don’t take the missed dose the subsequent morning till you examine together with your physician.
  • Don’t take a double dose to make up for the one that you just missed.
  • When you have bother remembering when to take your medication, ask your pharmacist for some hints.

Imipramine Generic Storage

  1. Preserve your tablets of their container till it’s time to take them. In case you take the tablets out of their container they might not preserve nicely.
  2. Retailer Imipramine in a cool dry place the place the temperature stays beneath 30°C. Defend from moisture.
  3. Don’t retailer this or some other medication within the lavatory or close to a sink. Don’t depart it within the automobile or on windowsills. Warmth and dampness can destroy some medicines.
  4. Preserve the tablets the place kids can’t attain them. A locked cabinet not less than 1½ metres above the bottom is an effective place to retailer medicines.

Disposal: In case your physician tells you to cease taking this medication otherwise you discover that the expiry date has handed, ask your pharmacist what to do with any tablets you’ve left over.

Imipramine Generic Precautions

  • Issues you could do
    • In case you grow to be pregnant whereas taking Imipramine, inform your physician instantly. Your physician can talk about with you the dangers of utilizing it while you’re pregnant.
    • Inform your physician if, for any purpose, you haven’t taken your medication precisely as prescribed. In any other case, your physician might imagine that it was not efficient and alter your remedy unnecessarily.
    • Inform your physician if you happen to really feel the tablets are usually not serving to your situation.
    • If you’re being handled for despair, be sure you talk about together with your physician any issues you might have and the way you are feeling, particularly any emotions of extreme disappointment or bursts of surprising vitality or anger. This can assist your physician to find out the perfect remedy for you.
    • Make sure you preserve your entire physician’s appointments in order that your progress could be checked. Your physician could wish to take some blood assessments and examine your coronary heart and blood stress every now and then. This helps to forestall undesirable negative effects.
    • Contact your physician instantly if you happen to or somebody develop any of the next signs at any time throughout remedy with Imipramine:
      • ideas about suicide or dying
      • makes an attempt to commit suicide
      • new or worse despair
      • new or worse nervousness
      • feeling very agitated or stressed
      • panic assaults
      • problem sleeping (insomnia)
      • new or worse irritability
      • performing aggressive, being indignant, or violent performing on harmful impulses
      • an excessive improve in exercise and speaking
      • different uncommon modifications in behaviour or temper.
      • Signs akin to these could also be related to an elevated danger of suicidal pondering and behavior and have to be taken significantly.
    • Earlier than having any surgical procedure or emergency remedy, even a minor process, inform the physician or dentist in cost that you’re taking Tofranil or have been taking it throughout the final two weeks or so. If potential, this medication ought to be stopped earlier than surgical procedure to keep away from pointless negative effects.
    • If this medication causes your mouth to really feel dry and this downside would not go away, inform your physician or dentist. Make sure you have common dental check-ups. Persevering with dryness of the mouth could improve the prospect of gum illness or cavities. You’ll be able to relieve dry mouth by frequent sips of water, sucking sugarless lollies or chewing sugarless gum.
    • In case you put on contact lenses and discover that your eyes are dry, sticky or irritated, inform your physician. These negative effects might injury your eyes.
    • If you’re about to be began on any new medication, remind your physician and pharmacist that you’re taking Imipramine.
    • Don’t take some other medicines, whether or not they require a prescription or not, with out first telling your physician.
    • Inform some other physician, dentist or pharmacist who treats you that you’re taking Tofranil.
  • Issues you could not do
    • Don’t cease taking Imipramine or change the dose with out first checking together with your physician. Don’t let your self run out of drugs over the weekend or on holidays.
      • In case you cease taking this medication instantly, your situation could worsen or you might have undesirable negative effects akin to headache, nausea (feeling sick), vomiting, diarrhoea and nervousness. If potential, your physician will steadily scale back the quantity you’re taking every day earlier than stopping the medication utterly.
    • Don’t take Tofranil to deal with some other complaints except your physician tells you to.
    • Don’t give this medication to anybody else, even when their signs appear just like yours or if they’ve the identical situation as you.

  • Issues to watch out of
    • You should inform your physician if you’re pregnant or are desiring to grow to be pregnant.
      • There have been reviews of some congenital abnormalities or a rise in pre-term supply related to taking antidepressants in being pregnant.
      • Some infants, uncovered to antidepressants late within the third trimester, have proven drug withdrawal signs akin to problem of respiration, sluggish, colic irritability, low or hypertension, and tremor or spasms.
      • Your physician will talk about the potential dangers and advantages of taking Imipramine throughout being pregnant.
    • Watch out driving, working equipment or doing jobs that require you to be alert while you’re taking Tofranil till you understand how it impacts you. Youngsters ought to take care when doing issues like using bicycles or climbing timber.
      • This medication could trigger tiredness, dizziness, drowsiness or blurred imaginative and prescient in some individuals.
    • Watch out when ingesting alcohol or taking ache relievers, sleeping tablets or antihistamines (medicines for colds or allergic reactions akin to hay fever) while you’re taking Imipramine.
      • This medication can improve the drowsiness attributable to alcohol and by medicines that have an effect on your nervous system.
    • If this medication makes you are feeling lightheaded, watch out when getting up from a sitting or mendacity place.
      • You’ll be able to normally stop these signs by getting up slowly and flexing leg muscle mass and toes to get the blood flowing. When getting off the bed, dangle your legs over the aspect for a minute or two earlier than standing up.
    • Watch out to remain out of direct daylight as a lot as potential till you discover out in case your pores and skin is extra delicate than normal. Put on protecting clothes and use a sunscreen. Don’t use a sunlamp.
      • This medication makes some individuals extra delicate to daylight.
    • After you’ve stopped taking Tofranil, it’s best to nonetheless watch out for 1 or 2 weeks since among the medication will nonetheless be in your physique.

Imipramine Generic Side Effects

Inform your physician or pharmacist as quickly as potential if you don’t really feel nicely while you’re taking Imipramine. Imipramine helps most individuals with despair, however it might have undesirable negative effects in some individuals. All medicines can have negative effects. Generally they’re critical, more often than not they don’t seem to be. You might want medical remedy if you happen to get among the negative effects.

If you’re over 65 years outdated, try to be particularly cautious whereas taking this medication. Report any negative effects promptly to your physician. As individuals get older, they’re extra prone to get negative effects from medicines.

Imipramine Tofranil could cause confusion or disorientation, particularly in older individuals. Your loved ones or carer ought to pay attention to this. Particular care could also be wanted. Don’t be alarmed by this listing of potential negative effects. You might not expertise any of them. Ask your physician or pharmacist to reply any questions you might have.

Inform your physician if you happen to discover any of those negative effects they usually fear you:

  • drowsiness, dizziness, blurred imaginative and prescient or problem focussing your eyes
  • palpitations
  • rash, hives
  • light-headedness, particularly while you rise up too shortly from a sitting or mendacity place
  • dry mouth
  • altered sense of style
  • issues with urinating (passing water)
  • dry or sticky eyes
  • constipation or diarrhoea
  • sweating or sizzling flushes
  • weight acquire
  • drained feeling
  • feeling of unrest or nervousness
  • hallucinations, feeling very confused
  • euphoria
  • disturbed sleep
  • temper swings
  • prickly pores and skin
  • nausea (feeling sick), vomiting, lack of urge for food or weight reduction
  • headache
  • lowered sexual need
  • irregular liver operate take a look at.
  • These are the extra widespread negative effects of Imipramine.


Information concerning psychotic disorders, included within the review of Imipramine, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.


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Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.

Frequently asked questions

  • What is Imipramine Generic?

     Imipramine belongs to the class of tricyclic antidepressants (TCAs). This medication is used to treat major depression, panic disorder and enuresis (inability to control urination). Imipramine can be also applied for other purposes.

  • What to do if you miss a dose?

    If you miss a dose of Imipramine Generic, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  • What if u take too much Imipramine Generic?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  • How to store Tofranil Generic?

    Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. 

  • What Should I Avoid While Taking Imipramine Generic?

    Marked drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquillizers may increase drowsiness excitability may occur, especially in children be careful when driving a motor vehicle or operating machinery 

  • What are the side effects of Tofranil Generic?

    The medication cannot be used in patients with hypersensitivity to the components of Imipramine Generic, in patients during acute recovery phase of myocardial infarction, and in patients treated by MAO inhibitors.

  • What are the Contraindication?

    Imipramine should not be used by pregnant/nursing women or children as well as by the patients having demonstrated a reaction of hypersensitivity to Imipramine.

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Last Updated on November 8, 2021 by Toni El Clikos

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