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What is Estrace or Estradiol?

Estrace belongs to the class of medications named estrogen replacement therapy. Estrogen is a hormone produced by the ovaries, specific estrogen-receptors are located in different organs (in the uterus, vagina, urethra, mammary glands, liver, hypothalamus, pituitary) and stimulates development and growth of female sex organs starting from puberty: uterus, fallopian tubes, vagina, stroma and ducts of mammary glands, pigmentation of nipples and genitals, the formation of secondary sexual characteristics of the female type, the formation of epiphyses of long bones. Estrogen is responsible for the timely and regular rejection of the endometrium and bleeding, in high concentrations estrogen causes endometrial hyperplasia, suppress lactation, inhibits bone resorption. Estrace is used to treat menopause symptoms which include hot flashes, and vaginal dryness, burning, and irritation. It is also used for the treatment of cancer treatment in women and men and osteoporosis.

Dosage and direction

Take exactly as prescribed by your doctor, follow all recommendations. Estrace tablets should be taken one time a day. In women, a cyclic regimen may be administered: 23 days the tablets are taken, followed by the next 5 days without any medication intake. After it, the cycle resumes. The adhesive part of the patch should be stuck to a hairless part of trunk (hips, shoulder but not on the breasts), choose non-irritated healthy skin site. Change the place of plaster application each other week. Stick it immediately to the skin after you removed a protective layer and press tight to your skin during at least 10 seconds.

Precautions

Before to take Estrace to inform your doctor if you have severe blood diseases, circulation problems, hormone-related cancer (breast or uterine cancer), or excessive vaginal bleeding. Long-term treatment by Estrace may result in an increased risk of breast cancer, heart attack, or stroke, cannot be used in pregnant women.

Contraindications

Hypersensitivity, pregnancy, estrogen depending malignant neoplasms, unusual or undiagnosed genital and uterine bleeding, thrombophlebitis or thromboembolic disease in active phase (excluding treatment of breast and prostate cancer). Carefulness should be exercised in patients with thrombophlebitis, thrombosis or thromboembolism (during the taking of estrogens in history); family hyperlipoproteinemia, pancreatitis, endometriosis, gallbladder r disease in history, severe liver failure, jaundice, hepatic porphyria, hypercalcemia associated with metastases in bones caused by breast cancer. Only for treatment of breast and prostate cancer: diseases of the coronary or cerebral vessels, active thrombophlebitis or thromboembolic disease.

Possible side effect

  • Common side effects include:
  • breast pain or tenderness;
  • headache;
  • hair loss;
  • spotting or breakthrough bleeding;
  • mild nausea or vomiting;
  • stomach cramps or bloating.

Serious side effects are allergic reactions:

  • rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue;
  • back pain;
  • breast discharge or lump in the breast;
  • calf or leg pain or swelling
  • chest pain;
  • coughing up blood
  • dark urine;
  • depression; dizziness;
  • fainting;
  • fever;
  • memory problems;
  • mental or mood changes;
  • muscle pain; one-sided weakness;
  • painful or difficult urination;
  • persistent or severe breast pain or tenderness;
  • persistent or severe headache, nausea, or vomiting;
  • severe stomach pain or swelling;
  • slurred speech;
  • sudden shortness of breath;
  • sunburn-like rash;
  • swelling of hands, legs, or feet;
  • unusual vaginal bleeding, discharge, itching, or odour;
  • vision changes;
  • vomiting;
  • weakness or numbness of an arm or leg;
  • yellowing of the skin or eyes.

Drug interaction

Estrogen can inhibit the metabolism of cyclosporine resulting in an increase of its levels in blood and kidney and/or liver damage. Estrogen are abler to increase the risk of liver disease in patients treated by dantrolene. Known to affect a clot formation Estrace should be used carefully together with warfarin (Coumadin). Enhanced metabolism and excretion of Estrace may be stipulated by rifampin, barbiturates, carbamazepine (Tegretol), griseofulvin, phenytoin (Dilantin) and primidone.

Missed dose

If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. If so skip the missed dose. Do not try to make up a missed dose by taking an extra one.

Overdose

If you suspect that you took too much of the medication seek for immediate medical attention. Your symptoms may appear as nausea, vomiting, or vaginal bleeding.

Storage

Store Estrace in a dry tight container away from sunlight at room temperature between 15-30 C (59-86 F) away from children and pets.

Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.


Frequently asked questions

What is Estrace?

You are using this medicine as a woman during menopause. The medicine contains estradiol, a primary form of estrogen. Estradiol is available in patches of 3.8 and 7.6 mg of estradiol or tablets. The patches release this substance gradually throughout the day. The patches containing 3.8 mg of Estrace release 50 micrograms per 24 hours and the patches containing 7.6 mg of estradiol release 100 micrograms per 24 hours. Look at all the different types of Estrace here.

Why and when should you use Estrace?

Estrace or Estradiol is a drug used to reduce menopause symptoms in women. Menopause is a process in the body where the ovaries stop producing eggs. As a result, the woman no longer has her monthly period and her periods will be irregular at first and then stop. The amount of estrogen gradually decreases in the body. This may also cause you to experience psychological and physical symptoms. This usually happens between the ages of 44 and 55.

How effective is Estrace?

Estrace is effective to treat menopause symptoms. The symptoms: stiff joints, mood swings, difficulty sleeping… will decrease when using this drug. Women can suffer greatly from these symptoms. This can have a psychological and a physical impact on their lives. In this case, it is advisable to take medication. In function of their well-being.. Look at all the different types of Estrace here.

What are the side effects of Estrace?

Like other medications, Estrace can have side effects. It is important to know about these beforehand so you know what to expect. Do you recognize signs of an allergic reaction (such as difficulty breathing or swelling in the mouth and throat), of a blood clot (such as chest pain) or of breast cancer (such as changes to the areola)? If so, get medical attention right away.
In addition, this medicine may cause the following side effects:

-Frequently (in 1 or more than 1 in 10 women): skin irritation, swelling or bleeding at the site of the patch, headache, painful or irregular menstruation;

-Regularly (in 1 or less than 1 in 10 women): trouble sleeping, depression, diarrhea, nausea, dry or itchy skin, rash, larger breasts, acne, irregular vaginal bleeding, violent contractions of the uterus, fluid retention, changes in weight, feeling weakened, pain in the limbs, back pain;

-Less frequently (in 1 or less than 1 in 100 women): feeling faint, migraines, hypertension (high blood pressure), vomiting, changed liver values on blood tests, skin discoloration;. Look at all the different types of Estrace here.

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Last Updated on August 29, 2021 by Toni El Clikos

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